Title :

Prospective, randomized, controlled, open-label study to compare efficacy of a mineral-rich solution vs normal saline after complete ethmoidectomy.

Author(s) :

De Gabory, Ludovic [Auteur]
Université de Bordeaux [UB]
Escabasse, Virginie [Auteur]
Boudard, Philippe [Auteur]
De Bonnecaze, Guillaume [Auteur]
Rumeau, Cecile [Auteur]
Jankowski, Roger [Auteur]
Debry, Christian [Auteur]
Moriniere, Sylvain [Auteur]
Merino, Bertrand [Auteur]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Malard, Olivier [Auteur]
Bordenave, Laurence [Auteur]
Université de Bordeaux [UB]

Journal title :

European Archives of Oto-Rhino-Laryngology

Abbreviated title :

Eur Arch Otorhinolaryngol

Volume number :

276

Pages :

447–457

Publication date :

2019-02-14

ISSN :

1434-4726

English keyword(s) :

Lund-Kennedy endoscopic score
Nasal polyposis
Chronic rhinosinusitis
Nasal irrigation
Mucociliary clearance

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: The purpose of this study was to compare the efficacy of a mineral-rich solution vs normal saline solution (0.9% NaCl) following endoscopic complete bilateral ethmoidectomy. METHODS: This was a prospective, ...
Show more >OBJECTIVE: The purpose of this study was to compare the efficacy of a mineral-rich solution vs normal saline solution (0.9% NaCl) following endoscopic complete bilateral ethmoidectomy. METHODS: This was a prospective, multicenter, randomized, controlled, open-label trial in subjects suffering from steroid-resistant sinonasal polyposis. Adults performed 4 nasal irrigations of mineral or saline solutions daily for 28 days. Evaluations included subject-reported RHINO quality of life (QoL) and NOSE scores, tolerability, and satisfaction, the Lund-Kennedy endoscopic score and assessments of crusting, secretions and mucociliary clearance (rhinoscintigraphy). RESULTS: A total of 189 subjects were randomized. Clinically relevant improvements (> 20 points) in RhinoQOL and NOSE scores were measured in both groups without any significant inter-group difference. Among the subjects with impaired RhinoQOL at pre-inclusion, the change in Impact-RhinoQOL score was significantly superior in mineral-rich vs saline solution at day 21 (p = 0.028) and day 28 (p = 0.027). The Lund-Kennedy score continuously improved in both groups earlier with the mineral-rich solution. Crusts were significantly fewer in number and less severe/obstructive in patients receiving mineral-rich vs saline solution at day 7 (p = 0.026) and day 14 (p = 0.016). Furthermore, secretions disappeared significantly more quickly and were less thick/purulent with mineral-rich solution at day 14 (p = 0.002) and day 21 (p = 0.043). Less epistaxis was reported in the mineral vs saline solution (p = 0.008 at day 21). CONCLUSIONS: Our findings indicate that the composition of a nasal irrigation solution influences endoscopic scores and QoL after sinus surgery for patients over 60, those with an initially poor QoL and higher symptom score, and smokers.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2019-10-22T08:16:44Z
2024-03-05T11:54:12Z