What criteria for an ideal antipsychotic treatment?

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.encep.2014.12.001

PMID :

Permalink :

http://hdl.handle.net/20.500.12210/15793

Title :

What criteria for an ideal antipsychotic treatment?

Author(s) :

Bordet, Regis [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

L'Encephale

Abbreviated title :

Enceph.-Rev. Psychiatr. Clin. Biol. Ther.

Volume number :

41

Pages :

39-46

Publication date :

2015-02-01

ISSN :

0013-7006

English keyword(s) :

Symptoms
Antipsychotic drugs
Side-effect
Long-term effect

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Antipsychotics are, by definition, drugs to treat all symptomatic dimensions of schizophrenia, even if, following the discovery of chlorpromazine, the effect assessment has been focused on the ability to reduce positive ...
Show more >Antipsychotics are, by definition, drugs to treat all symptomatic dimensions of schizophrenia, even if, following the discovery of chlorpromazine, the effect assessment has been focused on the ability to reduce positive symptoms. Nevertheless, expectations of treatment are no longer limited to only support this one dimension, but integrate the need to treat negative, cognitive and affective symptoms, through long-term modulation of dopamine transmission but also non-dopaminergic pathways. Beyond symptomatic treatment, it is also necessary to have a treatment modifying the evolution course of the disease (disease modifier), acting by a long-term effect on neuropathological and neurochemical abnormalities. The limitation of long-term effect remains the issue of therapeutic observance. Moreover, this concern for efficiency should be at the cost of reduced induction of adverse effects to maximize the benefit/risk ratio. All these dimensions should the components to profile an ideal antipsychotic treatment in 2015.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:01:27Z
2022-10-21T15:24:32Z

Version history