Clinical usefulness of dopamine transporter ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Clinical usefulness of dopamine transporter spect imaging with 123i-fp-cit in patients with possible dementia with lewy bodies: randomised study
Author(s) :
Walker, Zuzana [Auteur]
Moreno, Emilio [Auteur]
Thomas, Alan [Auteur]
Inglis, Fraser [Auteur]
Tabet, Naji [Auteur]
Rainer, Michael [Auteur]
Pizzolato, Gilberto [Auteur]
Padovani, Alessandro [Auteur]
Moreno, Emilio [Auteur]
Thomas, Alan [Auteur]
Inglis, Fraser [Auteur]
Tabet, Naji [Auteur]
Rainer, Michael [Auteur]
Pizzolato, Gilberto [Auteur]
Padovani, Alessandro [Auteur]
Journal title :
The British journal of psychiatry . the journal of mental science
Abbreviated title :
Br J Psychiatry
Volume number :
206
Pages :
145-52
Publication date :
2015-02-01
ISSN :
1472-1465
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Dementia with Lewy bodies (DLB) is underrecognised in clinical settings.
OBJECTIVE: To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission ...
Show more >BACKGROUND: Dementia with Lewy bodies (DLB) is underrecognised in clinical settings. OBJECTIVE: To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission computed tomography (SPECT) scan in patients with possible DLB would lead to a more certain diagnosis (probable DLB or non-DLB dementia). METHODS: We randomised 187 patients with possible DLB 2:1 to have a scan or not (control group). The outcome measure was a change in diagnosis to probable DLB or non-DLB. RESULTS: There were 56 controls and 114 scanned patients, of whom 43% had an abnormal scan. More patients in the imaging group had a change in diagnosis compared with controls at 8 and 24 weeks (61% (n = 70) v. 4% (n = 2) and 71% (n = 77) v. 16% (n = 9); both P<0.0001). Clinicians were more likely to change the diagnosis if the scan was abnormal (82%) than if it was normal (46%). CONCLUSIONS: Imaging significantly contributed to a more certain diagnosis, proving to be a useful adjunct in the work-up of patients with possible DLB.Show less >
Show more >BACKGROUND: Dementia with Lewy bodies (DLB) is underrecognised in clinical settings. OBJECTIVE: To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission computed tomography (SPECT) scan in patients with possible DLB would lead to a more certain diagnosis (probable DLB or non-DLB dementia). METHODS: We randomised 187 patients with possible DLB 2:1 to have a scan or not (control group). The outcome measure was a change in diagnosis to probable DLB or non-DLB. RESULTS: There were 56 controls and 114 scanned patients, of whom 43% had an abnormal scan. More patients in the imaging group had a change in diagnosis compared with controls at 8 and 24 weeks (61% (n = 70) v. 4% (n = 2) and 71% (n = 77) v. 16% (n = 9); both P<0.0001). Clinicians were more likely to change the diagnosis if the scan was abnormal (82%) than if it was normal (46%). CONCLUSIONS: Imaging significantly contributed to a more certain diagnosis, proving to be a useful adjunct in the work-up of patients with possible DLB.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T13:33:35Z