Diffusion weighted mri as an early predictor ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Diffusion weighted mri as an early predictor of tumor response to hypofractionated stereotactic boost for prostate cancer
Author(s) :
Pasquier, David [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Hadj Henni, Abderraouf [Auteur]
Escande, Alexandre [Auteur]
Tresch, Emmanuelle [Auteur]
Reynaert, Nick [Auteur]
Colot, Olivier [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189
Lartigau, Eric [Auteur]
Betrouni, Nacim [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]

Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Hadj Henni, Abderraouf [Auteur]
Escande, Alexandre [Auteur]
Tresch, Emmanuelle [Auteur]
Reynaert, Nick [Auteur]
Colot, Olivier [Auteur]

Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189
Lartigau, Eric [Auteur]

Betrouni, Nacim [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Journal title :
Scientific Reports
Abbreviated title :
Sci Rep
Volume number :
8
Pages :
10407
Publication date :
2018-07-10
ISSN :
2045-2322
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
We evaluated the feasibility of using the kinetic of diffusion-weighted MRI (DWI) and the normalized apparent coefficient diffusion (ADC) map value as an early biomarker in patients treated by external beam radiotherapy ...
Show more >We evaluated the feasibility of using the kinetic of diffusion-weighted MRI (DWI) and the normalized apparent coefficient diffusion (ADC) map value as an early biomarker in patients treated by external beam radiotherapy (EBRT). Twelve patients were included within the frame of a multicenter phase II trial and treated for intermediate risk prostate cancer (PCa). Multiparametric MRI was performed before treatment (M0) and every 6 months until M24. Association between nADC and PSA or PSA kinetic was evaluated using the test of nullity of the Spearman correlation coefficient. The median rates of PSA at the time of diagnosis, two years and four years after EBRT were 9.29 ng/ml (range from 5.26 to 17.67), 0.68 ng/ml (0.07-2.7), 0.47 ng/ml (0.09-1.39), respectively. Median nADC increased from 1.14 × 10-32-32-32-32Show less >
Show more >We evaluated the feasibility of using the kinetic of diffusion-weighted MRI (DWI) and the normalized apparent coefficient diffusion (ADC) map value as an early biomarker in patients treated by external beam radiotherapy (EBRT). Twelve patients were included within the frame of a multicenter phase II trial and treated for intermediate risk prostate cancer (PCa). Multiparametric MRI was performed before treatment (M0) and every 6 months until M24. Association between nADC and PSA or PSA kinetic was evaluated using the test of nullity of the Spearman correlation coefficient. The median rates of PSA at the time of diagnosis, two years and four years after EBRT were 9.29 ng/ml (range from 5.26 to 17.67), 0.68 ng/ml (0.07-2.7), 0.47 ng/ml (0.09-1.39), respectively. Median nADC increased from 1.14 × 10-32-32-32-32Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Centrale Lille
Inserm
Université de Lille
CNRS
Centrale Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T13:34:08Z
2021-06-08T10:00:29Z
2021-06-08T10:00:29Z