Post-stroke cognitive decline: an update and perspectives for clinical research

Brainin, Michael; Tuomilehto, J.; Heiss, Wolf-Dieter; Bornstein, Natan M.; Bath, Philip M. W.; Teuschl, Yvonne; Richard, Edo; Guekht, Alla; Quinn, Terry

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1111/ene.12626

PMID :

25492161

Permalink :

http://hdl.handle.net/20.500.12210/16171

Title :

Post-stroke cognitive decline: an update and perspectives for clinical research

Author(s) :

Brainin, Michael [Auteur]
Tuomilehto, J. [Auteur]
Heiss, Wolf-Dieter [Auteur]
Bornstein, Natan M. [Auteur]
Bath, Philip M. W. [Auteur]
Teuschl, Yvonne [Auteur]
Richard, Edo [Auteur]
Guekht, Alla [Auteur]
Quinn, Terry [Auteur]

Journal title :

European journal of neurology

Abbreviated title :

Eur. J. Neurol.

Volume number :

Pages :

229-38, e13-6

Publication date :

2015-02-01

ISSN :

1468-1331

English keyword(s) :

ischemic stroke
prevention
post-stroke dementia
mild vascular cognitive impairment

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The close relationship between stroke and dementia is an important health issue. Ischaemic stroke can facilitate the onset of vascular dementia as well as aggravate pre-existing cognitive decline. The onset of cognitive ...
Show more >The close relationship between stroke and dementia is an important health issue. Ischaemic stroke can facilitate the onset of vascular dementia as well as aggravate pre-existing cognitive decline. The onset of cognitive decline may become manifest immediately following the onset of ischaemic stroke, but often there is a delay in the development of cognitive decline after a stroke. This delay can be seen as a therapeutic time window allowing interventions to be applied to preserve cognition following stroke. Both neurodegenerative and vascular mechanisms are activated and probably result in overlapping processes within the neurovascular unit. This review focuses on the incidence and prevalence of cognitive decline following stroke, predisposing stroke aetiologies, pre-stroke decline, imaging factors and biomarkers. Outcomes are discussed in relation to timing of assessment and neuropsychological tests used for evaluation of cognitive decline in ischaemic stroke patients. Including such tests in routine evaluations of stroke patients after some weeks or months is recommended. Finally, an outlook on ongoing and planned intervention trials is added and some recommendations for future research are proposed.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:34:22Z

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