Title :

Apathy alters emotional arousal in chronic schizophrenia

Author(s) :

Dondaine, Thibaut [Auteur]
Philippot, Pierre [Auteur]
Batail, Jean-Marie [Auteur]
Le Jeune, Florence [Auteur]
Sauleau, Paul [Auteur]
Drapier, Sophie [Auteur]
Verin, Marc [Auteur]
Millet, Bruno [Auteur]
Drapier, Dominique [Auteur]
Robert, Gabriel [Auteur]

Journal title :

Journal of psychiatry & neuroscience . JPN

Abbreviated title :

J Psychiatry Neurosci

Volume number :

43

Pages :

170172

Publication date :

2018-10-02

ISSN :

1488-2434

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Within the heterogeneity of schizophrenia, apathy constitutes an independent cluster of negative symptoms associated with poor outcomes. Attempts to identify an emotional deficit in patients who have schizophrenia ...
Show more >BACKGROUND: Within the heterogeneity of schizophrenia, apathy constitutes an independent cluster of negative symptoms associated with poor outcomes. Attempts to identify an emotional deficit in patients who have schizophrenia with negative symptoms have yielded mixed results, and studies that focus on the relationship between apathy and emotional disorders are lacking. METHODS: We set out to remedy this shortcoming using a validated battery of film excerpts to induce positive and negative emotions in patients with chronic schizophrenia with (nnn RESULTS: Using a qualitative measure of apathy, we did not find a specific decrease in tonic activity during the induction of positive emotions. However, we did observe that patients with apathy showed reduced tonic activity independent of valence (i.e., for both positive and negative emotions) compared with controls and patients without apathy. Moreover, the quantitative measure of apathy (Apathy Evaluation Scale) was the only significant factor, explaining 24% of the variance in tonic activity during induction of positive emotions after controlling for confounding factors. CONCLUSIONS: Electrodermal activity was the only physiologic measure we acquired. We induced several emotions sequentially that might have overlapped with each other, but we added an emotional "washout" period and randomized the order of each film excerpt to limit this possibility. CONCLUSIONS: Taken together, these results suggest that apathy in schizophrenia could impair tonic activity during positive emotions. Treatments aimed at enhancing positive emotions may help alleviate apathy in schizophrenia.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:36:04Z
2020-02-19T12:36:28Z