Title :

Deficits of psychomotor and mnesic functions across aging in mouse lemur primates

Author(s) :

Languille, Solene [Auteur]
Lievin-Bazin, Agatha [Auteur]
Picq, Jean-Luc [Auteur]
Louis, Caroline [Auteur]
Dix, Sophie [Auteur]
De Barry, Jean [Auteur]
Blin, Olivier [Auteur]
Richardson, Jill C. [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Schenker, Esther [Auteur]
Djelti, Fathia [Auteur]
Aujard, Fabienne [Auteur]

Journal title :

Frontiers in behavioral neuroscience

Abbreviated title :

Front. Behav. Neurosci.

Volume number :

8

Publication date :

2015-01-09

ISSN :

1662-5153

English keyword(s) :

spatial memory
psychomotor
recognition memory
working memory
anxiety

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Owing to a similar cerebral neuro-anatomy, non-human primates are viewed as the most valid models for understanding cognitive deficits. This study evaluated psychomotor and mnesic functions of 41 young to old mouse lemurs ...
Show more >Owing to a similar cerebral neuro-anatomy, non-human primates are viewed as the most valid models for understanding cognitive deficits. This study evaluated psychomotor and mnesic functions of 41 young to old mouse lemurs (Microcebus murinus). Psychomotor capacities and anxiety-related behaviors decreased abruptly from middle to late adulthood. However, mnesic functions were not affected in the same way with increasing age. While results of the spontaneous alternation task point to a progressive and widespread age-related decline of spatial working memory, both spatial reference and novel object recognition (NOR) memory tasks did not reveal any tendency due to large inter-individual variability in the middle-aged and old animals. Indeed, some of the aged animals performed as well as younger ones, whereas some others had bad performances in the Barnes maze and in the object recognition test. Hierarchical cluster analysis revealed that declarative-like memory was strongly impaired only in 7 out of 25 middle-aged/old animals. These results suggest that this analysis allows to distinguish elder populations of good and bad performers in this non-human primate model and to closely compare this to human aging.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:37:11Z