Title :

Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets s2top-bleed

Author(s) :

Hilkens, Nina A. [Auteur]
Algra, Ale [Auteur]
Diener, Hans-Christoph [Auteur]
Reitsma, Johannes B. [Auteur]
Bath, Philip M. W. [Auteur]
Csiba, Laszlo [Auteur]
Hacke, Werner [Auteur]
Kappelle, L. Jaap [Auteur]
Koudstaal, Peter J. [Auteur]
LEYS, Didier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Mas, Jean-Louis [Auteur]
Sacco, Ralph L. [Auteur]
Amarenco, Pierre [Auteur]
Sissani, Leila [Auteur]
Greving, Jacoba P. [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

89

Pages :

936-943

Publication date :

2017-08-29

ISSN :

0028-3878

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents. METHODS: We combined individual patient data from 6 randomized clinical ...
Show more >OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents. METHODS: We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, and PRoFESS) investigating antiplatelet therapy after TIA or ischemic stroke. Cox regression analyses stratified by trial were performed to study the association between predictors and major bleeding. A risk prediction model was derived and validated in the PERFORM trial. Performance was assessed with the c RESULTS: Major bleeding occurred in 1,530 of the 43,112 patients during 94,833 person-years of follow-up. The observed 3-year risk of major bleeding was 4.6% (95% confidence interval [CI] 4.4%-4.9%). Predictors were male sex, smoking, type of antiplatelet agents (aspirin-clopidogrel), outcome on modified Rankin Scale ≥3, prior stroke, high blood pressure, lower body mass index, elderly, Asian ethnicity, and diabetes (S22cc CONCLUSIONS: The S2Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:28:37Z