Title :

Parkinson's disease genetic loci in rapid eye movement sleep behavior disorder

Author(s) :

Gan-Or, Ziv [Auteur]
Girard, Simon L. [Auteur]
Noreau, A. [Auteur]
Leblond, Claire S. [Auteur]
Gagnon, Jean-François [Auteur]
Arnulf, Isabelle [Auteur]
Mirarchi, C. [Auteur]
Dauvilliers, Yves [Auteur]
Desautels, Alex [Auteur]
Mitterling, T. [Auteur]
De Cock, Valerie Cochen [Auteur]
Frauscher, Birgit [Auteur]
Monaca, C. Charley [Auteur]
Hogl, Birgit [Auteur]
Dion, Patrick A. [Auteur]
Postuma, Ronald B. [Auteur]
Montplaisir, Jacques Y. [Auteur]
Rouleau, Guy A. [Auteur]

Journal title :

Journal of molecular neuroscience . MN

Abbreviated title :

J. Mol. Neurosci.

Volume number :

56

Pages :

617-622

Publication date :

2015-07-01

ISSN :

0895-8696

English keyword(s) :

Parkinson''s disease
REM sleep behavior disorder
Genetics
RBD

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Rapid eye movement (REM) sleep behavior disorder (RBD) is a prodromal condition for Parkinson's disease (PD) and other synucleinopathies, which often occurs many years before the onset of PD. We analyzed 261 RBD patients ...
Show more >Rapid eye movement (REM) sleep behavior disorder (RBD) is a prodromal condition for Parkinson's disease (PD) and other synucleinopathies, which often occurs many years before the onset of PD. We analyzed 261 RBD patients and 379 controls for nine PD-associated SNPs and examined their effects, first upon on RBD risk and second, on eventual progression to synucleinopathies in a prospective follow-up in a subset of patients. The SCARB2 rs6812193 (OR = 0.67, 95 % CI = 0.51-0.88, p = 0.004) and the MAPT rs12185268 (OR-0.43, 95 % CI-0.26-0.72, p = 0.001) were associated with RBD in different models. Kaplan-Meier survival analysis in a subset of RBD patients (n = 56), demonstrated that homozygous carriers of the USP25 rs2823357 SNP had progressed to synucleinopathies faster than others (log-rank p = 0.003, Breslow p = 0.005, Tarone-Ware p = 0.004). As a proof-of-concept study, these results suggest that RBD may be associated with at least a subset of PD-associated genes, and demonstrate that combining genetic and prodromal clinical data may help identifying individuals that are either more or less susceptible to develop synucleinopathies. More studies are necessary to replicate these results, and identify more genetic factors affecting progression from RBD to synucleinopathies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:29:10Z