Brain networks are independently modulated ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Brain networks are independently modulated by donepezil, sleep, and sleep deprivation
Auteur(s) :
Wirsich, Jonathan [Auteur]
Rey, Marc [Auteur]
Guye, Maxime [Auteur]
Benar, Christian [Auteur]
Lanteaume, Laura [Auteur]
Ridley, Ben [Auteur]
Confort-Gouny, Sylviane [Auteur]
Casse-Perrot, Catherine [Auteur]
Soulier, Elisabeth [Auteur]
Viout, Patrick [Auteur]
Rouby, Franck [Auteur]
Lefebvre, Marie-Noelle [Auteur]
Audebert, Christine [Auteur]
Truillet, Romain [Auteur]
Jouve, Elisabeth [Auteur]
Payoux, Pierre [Auteur]
Bartres-Faz, David [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Richardson, Jill C. [Auteur]
Babiloni, Claudio [Auteur]
Rossini, Paolo Maria [Auteur]
Micallef, Joelle [Auteur]
Blin, Olivier [Auteur]
Ranjeva, Jean-Philippe [Auteur]
Rey, Marc [Auteur]
Guye, Maxime [Auteur]
Benar, Christian [Auteur]
Lanteaume, Laura [Auteur]
Ridley, Ben [Auteur]
Confort-Gouny, Sylviane [Auteur]
Casse-Perrot, Catherine [Auteur]
Soulier, Elisabeth [Auteur]
Viout, Patrick [Auteur]
Rouby, Franck [Auteur]
Lefebvre, Marie-Noelle [Auteur]
Audebert, Christine [Auteur]
Truillet, Romain [Auteur]
Jouve, Elisabeth [Auteur]
Payoux, Pierre [Auteur]
Bartres-Faz, David [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Richardson, Jill C. [Auteur]
Babiloni, Claudio [Auteur]
Rossini, Paolo Maria [Auteur]
Micallef, Joelle [Auteur]
Blin, Olivier [Auteur]
Ranjeva, Jean-Philippe [Auteur]
Titre de la revue :
Brain topography
Nom court de la revue :
Brain Topogr
Date de publication :
2017-11-23
ISSN :
1573-6792
Mot(s)-clé(s) en anglais :
Donepezil
Functional connectivity
EEG-fMRI
Memantine
Sleep
Functional connectivity
EEG-fMRI
Memantine
Sleep
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with ...
Lire la suite >Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer's disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative 'PharmaCog'. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.Lire moins >
Lire la suite >Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer's disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative 'PharmaCog'. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Équipe(s) de recherche :
Troubles cognitifs dégénératifs et vasculaires
Date de dépôt :
2019-11-27T14:30:30Z