Relevance of follow-up in patients with ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Relevance of follow-up in patients with core clinical criteria for alzheimer disease and normal csf biomarkers
Auteur(s) :
Vercruysse, Olivier [Auteur]
Paquet, Claire [Auteur]
Gabelle, Audrey [Auteur]
Delbeuck, Xavier [Auteur]
Blanc, Frederic [Auteur]
Wallon, David [Auteur]
Dumurgier, Julien [Auteur]
Magnin, Eloi [Auteur]
Martinaud, Olivier [Auteur]
Jung, Barbara [Auteur]
Bousiges, Olivier [Auteur]
Lehmann, Sylvain [Auteur]
Delaby, Constance [Auteur]
Quillard-Muraine, Muriel [Auteur]
Peoc'h, Katell [Auteur]
Laplanche, Jean-Louis [Auteur]
Bouaziz-Amar, Elodie [Auteur]
Hannequin, Didier [Auteur]
Sablonniere, Bernard [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition (LilNCog) - U 1172
Buee, Luc [Auteur]
Hugon, Jacques [Auteur]
Schraen, Susanna [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Bombois, Stephanie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Paquet, Claire [Auteur]
Gabelle, Audrey [Auteur]
Delbeuck, Xavier [Auteur]
Blanc, Frederic [Auteur]
Wallon, David [Auteur]
Dumurgier, Julien [Auteur]
Magnin, Eloi [Auteur]
Martinaud, Olivier [Auteur]
Jung, Barbara [Auteur]
Bousiges, Olivier [Auteur]
Lehmann, Sylvain [Auteur]
Delaby, Constance [Auteur]
Quillard-Muraine, Muriel [Auteur]
Peoc'h, Katell [Auteur]
Laplanche, Jean-Louis [Auteur]
Bouaziz-Amar, Elodie [Auteur]
Hannequin, Didier [Auteur]
Sablonniere, Bernard [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition (LilNCog) - U 1172
Buee, Luc [Auteur]
Hugon, Jacques [Auteur]
Schraen, Susanna [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Bombois, Stephanie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Titre de la revue :
Current Alzheimer Research
Nom court de la revue :
Curr Alzheimer Res
Date de publication :
2018-01-09
ISSN :
1875-5828
Mot(s)-clé(s) en anglais :
cerebrospinal fluid
Alzheimer disease
dementia
mild cognitive impairment
biomarker
depression
frontotemporal dementia
vascular dementia
Alzheimer disease
dementia
mild cognitive impairment
biomarker
depression
frontotemporal dementia
vascular dementia
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Few patients with a normal cerebrospinal fluid (CSF) biomarker profile fulfill the clinical criteria for Alzheimer disease (AD).
The aim of this study was to test the hypothesis of misdiagnoses for these patients.
Patients ...
Lire la suite >Few patients with a normal cerebrospinal fluid (CSF) biomarker profile fulfill the clinical criteria for Alzheimer disease (AD). The aim of this study was to test the hypothesis of misdiagnoses for these patients. Patients from the e-PLM centers fulfilling the core clinical criteria for probable AD dementia or mild cognitive impairment due to AD (AD-MCI), with normal CSF Aβ1-42, T-tau and P-tau biomarkers and clinical follow-up, were included. Clinical and imaging data were reviewed by an independent board, from baseline (visit with clinical evaluation and CSF analysis) to the end of the follow-up, for a final diagnosis. In the e-PLM cohort of 1098 AD patients with CSF analysis, 37 (3.3%) patients (20 with AD dementia core clinical criteria and 17 with AD-MCI core clinical criteria) had normal CSF biomarker profile and a clinical follow-up. All patients presented with episodic memory impairment and 27 (73%) had medial temporal lobe atrophy on MRI-scan. After a median follow-up of 36 months (range 7-74), the final diagnosis was AD MCI or dementia for 9 (24%) patients, and unlikely due to AD for 28 (76%) patients. A misdiagnosis was corrected in 18 (49%) patients (mood disorders, non-AD degenerative dementia, vascular cognitive impairment, alcohol cognitive disorders, temporal epilepsy and hippocampal sclerosis), and 10 (27%) patients had cognitive disorders of undetermined etiology. AD diagnosis (MCI or dementia) with normal CSF biomarkers is a rare condition. A clinical follow- up is particularly recommended to consider an alternative diagnosis.Lire moins >
Lire la suite >Few patients with a normal cerebrospinal fluid (CSF) biomarker profile fulfill the clinical criteria for Alzheimer disease (AD). The aim of this study was to test the hypothesis of misdiagnoses for these patients. Patients from the e-PLM centers fulfilling the core clinical criteria for probable AD dementia or mild cognitive impairment due to AD (AD-MCI), with normal CSF Aβ1-42, T-tau and P-tau biomarkers and clinical follow-up, were included. Clinical and imaging data were reviewed by an independent board, from baseline (visit with clinical evaluation and CSF analysis) to the end of the follow-up, for a final diagnosis. In the e-PLM cohort of 1098 AD patients with CSF analysis, 37 (3.3%) patients (20 with AD dementia core clinical criteria and 17 with AD-MCI core clinical criteria) had normal CSF biomarker profile and a clinical follow-up. All patients presented with episodic memory impairment and 27 (73%) had medial temporal lobe atrophy on MRI-scan. After a median follow-up of 36 months (range 7-74), the final diagnosis was AD MCI or dementia for 9 (24%) patients, and unlikely due to AD for 28 (76%) patients. A misdiagnosis was corrected in 18 (49%) patients (mood disorders, non-AD degenerative dementia, vascular cognitive impairment, alcohol cognitive disorders, temporal epilepsy and hippocampal sclerosis), and 10 (27%) patients had cognitive disorders of undetermined etiology. AD diagnosis (MCI or dementia) with normal CSF biomarkers is a rare condition. A clinical follow- up is particularly recommended to consider an alternative diagnosis.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Équipe(s) de recherche :
Alzheimer et Tauopathies
Troubles cognitifs dégénératifs et vasculaires
Troubles cognitifs dégénératifs et vasculaires
Date de dépôt :
2019-11-27T14:30:34Z