Title :

The dementia-associated apoe epsilon 4 allele is not associated with rapid eye movement sleep behavior disorder

Author(s) :

Gan-Or, Ziv [Auteur]
Montplaisir, Jacques Y. [Auteur]
Ross, Jay P. [Auteur]
Poirier, Judes [Auteur]
Warby, Simon C. [Auteur]
Arnulf, Isabelle [Auteur]
Strong, Stéphanie [Auteur]
Dauvilliers, Yves [Auteur]
Leblond, Claire S. [Auteur]
Hu, Michele T. M. [Auteur]
Hogl, Birgit [Auteur]
Stefani, Ambra [Auteur]
Meriaux, Christelle [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
De Cock, Valerie Cochen [Auteur]
Boivin, Michel [Auteur]
Ferini-Strambi, Luigi [Auteur]
Plazzi, Giuseppe [Auteur]
Antelmi, Elena [Auteur]
Young, Peter [Auteur]
Heidbreder, Anna [Auteur]
Barber, Thomas R. [Auteur]
Evetts, Samuel G. [Auteur]
Rolinski, Michal [Auteur]
Dion, Patrick A. [Auteur]
Desautels, Alex [Auteur]
Gagnon, Jean-François [Auteur]
Dupre, Nicolas [Auteur]
Postuma, Ronald B. [Auteur]
Rouleau, Guy A. [Auteur]

Journal title :

Neurobiology of aging

Abbreviated title :

Neurobiol. Aging

Volume number :

49

Publication date :

2017-01-01

ISSN :

0197-4580

English keyword(s) :

REM sleep behavior disorder
APOE
Parkinson''s disease
Dementia with Lewy bodies
Genetics

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement ...
Show more >The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:31:34Z