Title :

Full sequencing and haplotype analysis of mapt in parkinson''''s disease and rapid eye movement sleep behavior disorder

Author(s) :

Li, Jiao [Auteur]
Ruskey, Jennifer A. [Auteur]
Arnulf, Isabelle [Auteur]
Dauvilliers, Yves [Auteur]
Hu, Michele T. M. [Auteur]
Hogl, Birgit [Auteur]
Leblond, Claire S. [Auteur]
Zhou, Sirui [Auteur]
Ambalavanan, Amirthagowri [Auteur]
Ross, Jay P. [Auteur]
Bourassa, Cynthia V. [Auteur]
Spiegelman, Dan [Auteur]
Laurent, Sandra B. [Auteur]
Stefani, Ambra [Auteur]
Meriaux, Christelle [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
De Cock, Valerie Cochen [Auteur]
Boivin, Michel [Auteur]
Ferini-Strambi, Luigi [Auteur]
Plazzi, Giuseppe [Auteur]
Antelmi, Elena [Auteur]
Young, Peter [Auteur]
Heidbreder, Anna [Auteur]
Labbe, Catherine [Auteur]
Ferman, Tanis J. [Auteur]
Dion, Patrick A. [Auteur]
Fan, Dongsheng [Auteur]
Desautels, Alex [Auteur]
Gagnon, Jean-François [Auteur]
Dupre, Nicolas [Auteur]
Fon, Edward A. [Auteur]
Montplaisir, Jacques Y. [Auteur]
Boeve, Bradley F. [Auteur]
Postuma, Ronald B. [Auteur]
Rouleau, Guy A. [Auteur]
Ross, Owen A. [Auteur]
Gan-Or, Ziv [Auteur]

Journal title :

Movement disorders . official journal of the Movement Disorder Society

Abbreviated title :

Mov. Disord.

Volume number :

33

Pages :

1016-1020

Publication date :

2018-06-01

ISSN :

0885-3185

English keyword(s) :

REM sleep behavior disorder
Parkinson''s disease
genetics
MAPT

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: MAPT haplotypes are associated with PD, but their association with rapid eye movement sleep behavior disorder is unclear. OBJECTIVE: To study the role of MAPT variants in rapid eye movement sleep behavior ...
Show more >BACKGROUND: MAPT haplotypes are associated with PD, but their association with rapid eye movement sleep behavior disorder is unclear. OBJECTIVE: To study the role of MAPT variants in rapid eye movement sleep behavior disorder. METHODS: Two cohorts were included: (A) PD (n = 600), rapid eye movement sleep behavior disorder (n = 613) patients, and controls (n = 981); (B) dementia with Lewy bodies patients with rapid eye movement sleep behavior disorder (n = 271) and controls (n = 950). MAPT-associated variants and the entire coding sequence of MAPT were analyzed. Age-, sex-, and ethnicity-adjusted analyses were performed to examine the association between MAPT, PD, and rapid eye movement sleep behavior disorder. RESULTS: MAPT-H2 variants were associated with PD (odds ratios: 0.62-0.65; P = 0.010-0.019), but not with rapid eye movement sleep behavior disorder. In PD, the H1 haplotype odds ratio was 1.60 (95% confidence interval: 1.12-2.28; P = 0.009), and the H2 odds ratio was 0.68 (95% confidence interval: 0.48-0.96; P = 0.03). The H2/H1 haplotypes were not associated with rapid eye movement sleep behavior disorder. CONCLUSIONS: Our results confirm the protective effect of the MAPT-H2 haplotype in PD, and define its components. Furthermore, our results suggest that MAPT does not play a major role in rapid eye movement sleep behavior disorder, emphasizing different genetic background than in PD in this locus. © 2018 International Parkinson and Movement Disorder Society.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:33:00Z