Title :

Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

Author(s) :

De Guio, François [Auteur]
Jouvent, Eric [Auteur]
Biessels, Geert Jan [Auteur]
Black, Sandra E. [Auteur]
Brayne, Carol [Auteur]
Chen, Christopher [Auteur]
Cordonnier, Charlotte [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
De Leeuw, Frank-Erik [Auteur]
Dichgans, Martin [Auteur]
Doubal, Fergus N. [Auteur]
Duering, Marco [Auteur]
Dufouil, Carole [Auteur]
Duzel, Emrah [Auteur]
Fazekas, Franz [Auteur]
Hachinski, Vladimir [Auteur]
Ikram, Mohammad Arfan [Auteur]
Linn, Jennifer [Auteur]
Matthews, Paul M. [Auteur]
Mazoyer, Bernard [Auteur]
Mok, Vincent C. T. [Auteur]
Norrving, Bo [Auteur]
O'brien, John T. [Auteur]
Pantoni, Leonardo [Auteur]
Ropele, Stefan [Auteur]
Sachdev, Perminder S. [Auteur]
Schmidt, Reinhold [Auteur]
Seshadri, Sudha [Auteur]
Smith, Eric E. [Auteur]
Sposato, Luciano A. [Auteur]
Stephan, Blossom [Auteur]
Swartz, Richard H. [Auteur]
Tzourio, Christophe [Auteur]
Van Buchem, Mark [Auteur]
Van Der Lugt, Aad [Auteur]
Van Oostenbrugge, Robert J. [Auteur]
Vernooij, Meike W. [Auteur]
Viswanathan, Anand [Auteur]
Werring, David J. [Auteur]
Wollenweber, Frank Arne [Auteur]
Wardlaw, Joanna M. [Auteur]
Chabriat, Hugues [Auteur]

Journal title :

Journal of cerebral blood flow and metabolism . official journal of the International Society of Cerebral Blood Flow and Metabolism

Abbreviated title :

J. Cereb. Blood Flow Metab.

Volume number :

36

Pages :

1319-1337

Publication date :

2016-08-01

ISSN :

0271-678X

English keyword(s) :

reproducibility
lacunes
microbleeds
white matter hyperintensities
atrophy
brain volume
marker
cerebral small vessel disease
Magnetic resonance imaging
repeatability
variability
perivascular spaces

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, ...
Show more >Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:33:22Z
2020-02-19T10:30:47Z