Predicting major bleeding in patients with ...
Document type :
Article dans une revue scientifique: Article original
PMID :
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Title :
Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets s2top-bleed
Author(s) :
Hilkens, Nina A. [Auteur]
Algra, Ale [Auteur]
Diener, Hans-Christoph [Auteur]
Reitsma, Johannes B. [Auteur]
Bath, Philip M. [Auteur]
Csiba, Laszlo [Auteur]
Hacke, Werner [Auteur]
Kappelle, L. Jaap [Auteur]
Koudstaal, Peter J. [Auteur]
LEYS, Didier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Mas, Jean-Louis [Auteur]
Sacco, Ralph L. [Auteur]
Amarenco, Pierre [Auteur]
Sissani, Leila [Auteur]
Greving, Jacoba P. [Auteur]
Algra, Ale [Auteur]
Diener, Hans-Christoph [Auteur]
Reitsma, Johannes B. [Auteur]
Bath, Philip M. [Auteur]
Csiba, Laszlo [Auteur]
Hacke, Werner [Auteur]
Kappelle, L. Jaap [Auteur]
Koudstaal, Peter J. [Auteur]
LEYS, Didier [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Mas, Jean-Louis [Auteur]
Sacco, Ralph L. [Auteur]
Amarenco, Pierre [Auteur]
Sissani, Leila [Auteur]
Greving, Jacoba P. [Auteur]
Journal title :
Neurology
Abbreviated title :
Neurology
Volume number :
89
Pages :
936-943
Publication date :
2017-08-29
ISSN :
0028-3878
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents.
METHODS: We combined individual patient data from 6 randomized clinical ...
Show more >OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents. METHODS: We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, and PRoFESS) investigating antiplatelet therapy after TIA or ischemic stroke. Cox regression analyses stratified by trial were performed to study the association between predictors and major bleeding. A risk prediction model was derived and validated in the PERFORM trial. Performance was assessed with the c RESULTS: Major bleeding occurred in 1,530 of the 43,112 patients during 94,833 person-years of follow-up. The observed 3-year risk of major bleeding was 4.6% (95% confidence interval [CI] 4.4%-4.9%). Predictors were male sex, smoking, type of antiplatelet agents (aspirin-clopidogrel), outcome on modified Rankin Scale ≥3, prior stroke, high blood pressure, lower body mass index, elderly, Asian ethnicity, and diabetes (S22cc CONCLUSIONS: The S2Show less >
Show more >OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents. METHODS: We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, and PRoFESS) investigating antiplatelet therapy after TIA or ischemic stroke. Cox regression analyses stratified by trial were performed to study the association between predictors and major bleeding. A risk prediction model was derived and validated in the PERFORM trial. Performance was assessed with the c RESULTS: Major bleeding occurred in 1,530 of the 43,112 patients during 94,833 person-years of follow-up. The observed 3-year risk of major bleeding was 4.6% (95% confidence interval [CI] 4.4%-4.9%). Predictors were male sex, smoking, type of antiplatelet agents (aspirin-clopidogrel), outcome on modified Rankin Scale ≥3, prior stroke, high blood pressure, lower body mass index, elderly, Asian ethnicity, and diabetes (S22cc CONCLUSIONS: The S2Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Submission date :
2019-12-09T16:55:13Z