Title :

Wide variation in severe neonatal morbidity among very preterm infants in european regions

Author(s) :

Edstedt Bonamy, Anna-Karin [Auteur]
Karolinska Institutet [Stockholm]
Zeitlin, Jennifer [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Piedvache, Aurelie [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Maier, Rolf F. [Auteur]

Van Heijst, Arno [Auteur]
Radboud University Medical Center [Nijmegen]
Varendi, Heili [Auteur]
University of Tartu
Manktelow, Bradley N. [Auteur]
University of Leicester
Fenton, Alan [Auteur]
Newcastle University [Newcastle]
Mazela, Jan [Auteur]
IRCCS Ospedale Pediatrico Bambino Gesù [Roma]
Cuttini, Marina [Auteur]
Poznan University of Medical Sciences [Poland] [PUMS]
Norman, Mikael [Auteur]
Karolinska Institutet [Stockholm]
Petrou, Stavros [Auteur]
University of Warwick [Coventry]
Van Reempts, Patrick [Auteur]
University of Antwerp [UA]
Barros, Henrique [Auteur]

Draper, Elizabeth S. [Auteur]
University of Leicester
Martens, E. [Auteur]
Martens, G. [Auteur]
Boerch, K. [Auteur]
Hvidovre Hospital
Hasselager, A. [Auteur]
Huusom, L. [Auteur]
Hvidovre Hospital
Pryds, O. [Auteur]
Hvidovre Hospital
Weber, Tom [Auteur]
Hvidovre Hospital
Toome, Liis [Auteur]
University of Tartu
Ancel, Pierre-Yves [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Blondel, Béatrice [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Burguet, Antoine [Auteur]
CHU Dijon
Jarreau, Pierre-Henri [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Truffert, Patrick [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Schmidt, S. [Auteur]
Gortner, Ludwig [Auteur]
Saarland University [Saarbrücken]
Baronciani, D. [Auteur]
Gargano, G. [Auteur]
Agostino, R. [Auteur]
Dilallo, D. [Auteur]
Franco, F. [Auteur]
Carnielli, V. [Auteur]
Istituto Nazionale di Riposo e Cura per Anziani di Ancona
Koopman-Esseboom, C. [Auteur]
University Medical Center [Utrecht]
Nijman, J. [Auteur]
Gadzinowski, Janusz [Auteur]
Poznan University of Medical Sciences [Poland] [PUMS]
Mazela, Jan [Auteur]
Poznan University of Medical Sciences [Poland] [PUMS]
Graca, L. M. [Auteur]
Machado, M. C. [Auteur]
Université de Lisbonne
Rodrigues, Carina [Auteur]

Rodrigues, T. [Auteur]
Hospital de São João [Porto]
Wilson, Emilija [Auteur]
Karolinska University Hospital [Stockholm]
Boyle, Eileen Mary [Auteur]
Draper, Elizabeth S. [Auteur]
University of Leicester
Milligan, D. W. A. [Auteur]
Royal Victoria Hospital
Bonet, Mercedes [Auteur]

Journal title :

Archives of disease in childhood. Fetal and neonatal edition

Abbreviated title :

Arch. Dis. Child.-Fetal Neonatal Ed.

Volume number :

104

Pages :

F36-F45

Publication date :

2019-01-01

ISSN :

1359-2998

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality ...
Show more >OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. METHODS: Area-based cohort study of all births before 32 weeks of gestational age. METHODS: 16 regions in 11 European countries in 2011/2012. METHODS: Survivors to discharge from neonatal care (n=6422). METHODS: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. RESULTS: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P<0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50). CONCLUSIONS: Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T16:55:44Z
2020-06-08T09:28:08Z