Title :

Risk factors for acquisition of oxa-48-producing klebsiella pneumonia among contact patients: a multicentre study

Author(s) :

Hilliquin, D. [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Le Guern, Rémi [Auteur]
Recherche translationelle relations hôte-pathogènes
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Seegers, V. Thepot [Auteur]
Institut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO]
Neulier, Caroline [Auteur]
Lomont, A. [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Marie, V. [Auteur]
CHU de Bordeaux Pellegrin [Bordeaux]
Legeay, C. [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Merrer, Jacques [Auteur]
Lepelletier, Didier [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Rogues, A. M. [Auteur]
CHU de Bordeaux Pellegrin [Bordeaux]
Grandbastien, Bruno [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lucet, Jean-Christophe [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Zahar, Jean-Ralph [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]

Journal title :

The Journal of hospital infection

Abbreviated title :

J. Hosp. Infect.

Volume number :

98

Pages :

253-259

Publication date :

2018-03-01

ISSN :

0195-6701

English keyword(s) :

Screening
Contact patients
Carbapenemases
OXA-48
Carbapenemase-producing
Risk factors
Enterobacteriaceae
Mesh:beta-Lactamases/analysis*
Mesh:Aged
Mesh:80 and over
Mesh:Case-Control Studies
Mesh:Aged
Mesh:Adult
Mesh:Young Adult
Mesh:Risk Factors
Mesh:Humans
Mesh:Retrospective Studies
Mesh:Middle Aged
Mesh:Klebsiella pneumoniae/isolation & purification*
Mesh:Klebsiella pneumoniae/enzymology*
Mesh:Klebsiella Infections/microbiology*
Mesh:Klebsiella Infections/epidemiology*

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Cohorting carbapenemase-producing Enterobacteriaceae (CPE) carriers during hospitalization limits in-hospital spreading. OBJECTIVE: To identify risk factors for CPE acquisition among contacts of an index patient ...
Show more >BACKGROUND: Cohorting carbapenemase-producing Enterobacteriaceae (CPE) carriers during hospitalization limits in-hospital spreading. OBJECTIVE: To identify risk factors for CPE acquisition among contacts of an index patient in non-cohorted populations. METHODS: A multicentre retrospective matched case-control study was conducted in five hospitals. Each contact patient (case) who acquired Klebsiella pneumoniae (KP)-OXA-48 from an index patient was compared to three contact (controls) with the same index patients matched with hospitalization in the same unit and similar exposure times. RESULTS: Fifty-one secondary cases and 131 controls were included. By univariate analysis, exposure time (odds ratio: 1.06; 95% confidence interval: 1.02-1.1; P = 0.006), concomitant infection at admission (3.23; 1.42-7.35; P = 0.005), antimicrobial therapy within the last month before hospitalization (2.88; 1.34-6.2; P = 0.007), antimicrobial therapy during the exposure time (5.36; 2.28-12.6; P < 0.001), use of at least one invasive procedure (2.99; 1.25-7.15; P = 0.014), number of invasive procedures (1.52; 1.05-2.19; P = 0.025), and geographical proximity (2.84; 1.15-7.00; P = 0.023) were associated with CPE acquisition. By multivariate analysis, antimicrobial therapy during the exposure time (odds ratio: 6.36; 95% confidence interval: 2.46-16.44; P < 0.001), at least one invasive procedure (2.92; 1.04-8.17; P = 0.041), and geographical proximity (3.69; 1.15-11.86; P = 0.028) were associated with acquisition. CONCLUSIONS: In this study, geographical proximity, invasive procedure, and antimicrobial therapy during exposure time were significantly associated with KP-OXA-48 acquisition.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• Autres travaux scientifiques

Submission date :

2019-12-09T18:17:53Z
2020-04-30T07:59:09Z