The age of blood in pediatric intensive ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
The age of blood in pediatric intensive care units (abc picu): study protocol for a randomized controlled trial
Author(s) :
Tucci, Marisa [Auteur]
CHU Sainte Justine [Montréal]
Lacroix, Jacques [Auteur]
CHU Sainte Justine [Montréal]
Fergusson, Dean A. [Auteur]
The Ottawa Hospital
University of Ottawa [Ottawa]
Doctor, Allan [Auteur]
Hebert, Paul C. [Auteur]
Berg, Robert A. [Auteur]
Hospital of the University of Pennsylvania [HUP]
Caro, Jaime [Auteur]
Josephson, Cassandra D. [Auteur]
Centers for Disease Control and Prevention [Atlanta] [CDC]
Leteurtre, Stephane [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Menon, Kusum [Auteur]
The Ottawa Hospital
University of Ottawa [Ottawa]
Schechtman, Kenneth [Auteur]
Steiner, Marie E. [Auteur]
University of Minnesota Medical School
Turgeon, Alexis F. [Auteur]
Faculté de médecine de l'Université Laval [Québec] [ULaval]
Clayton, Lucy [Auteur]
CHU Sainte Justine [Montréal]
Bockelmann, Tina [Auteur]
Spinella, Philip C. [Auteur]
CHU Sainte Justine [Montréal]
Lacroix, Jacques [Auteur]
CHU Sainte Justine [Montréal]
Fergusson, Dean A. [Auteur]
The Ottawa Hospital
University of Ottawa [Ottawa]
Doctor, Allan [Auteur]
Hebert, Paul C. [Auteur]
Berg, Robert A. [Auteur]
Hospital of the University of Pennsylvania [HUP]
Caro, Jaime [Auteur]
Josephson, Cassandra D. [Auteur]
Centers for Disease Control and Prevention [Atlanta] [CDC]
Leteurtre, Stephane [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Menon, Kusum [Auteur]
The Ottawa Hospital
University of Ottawa [Ottawa]
Schechtman, Kenneth [Auteur]
Steiner, Marie E. [Auteur]
University of Minnesota Medical School
Turgeon, Alexis F. [Auteur]
Faculté de médecine de l'Université Laval [Québec] [ULaval]
Clayton, Lucy [Auteur]
CHU Sainte Justine [Montréal]
Bockelmann, Tina [Auteur]
Spinella, Philip C. [Auteur]
Journal title :
Trials
Abbreviated title :
Trials
Volume number :
19
Publication date :
2018-07-28
ISSN :
1745-6215
English keyword(s) :
Critical care
Randomized controlled trial
Study protocol
Transfusion
Mortality
Children
Blood
Intensive care
Red blood cell (RBC)
Erythrocyte
Randomized controlled trial
Study protocol
Transfusion
Mortality
Children
Blood
Intensive care
Red blood cell (RBC)
Erythrocyte
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: The "Age of Blood in Children in Pediatric Intensive Care Unit" (ABC PICU) study is a randomized controlled trial (RCT) that aims to determine if red blood cell (RBC) unit storage age affects outcomes in ...
Show more >BACKGROUND: The "Age of Blood in Children in Pediatric Intensive Care Unit" (ABC PICU) study is a randomized controlled trial (RCT) that aims to determine if red blood cell (RBC) unit storage age affects outcomes in critically ill children. While RBCs can be stored for up to 42 days in additive solutions, their efficacy and safety after long-term storage have been challenged. Preclinical and clinical observational evidence suggests loss of efficacy and lack of safety of older RBC units, especially in more vulnerable populations such as critically ill children. Because there is a belief that shorter storage will improve outcomes, some physicians and institutions systematically transfuse fresh RBCs to children. Conversely, the standard practice of blood banks is to deliver the oldest available RBC unit (first-in, first-out policy) in order to decrease wastage. METHODS: The ABC PICU study, is a double-blind superiority trial comparing the development of "New or Progressive Multiple Organ Dysfunction Syndrome" (NPMODS) in 1538 critically ill children randomized to either transfusion with RBCs stored for ≤ 7 days or to standard-issue RBCs (oldest in inventory). Patients are being recruited from 52 centers in the US, Canada, France, Italy, and Israel. CONCLUSIONS: The ABC PICU study should have significant implications for blood procurement services. A relative risk reduction of 33% is postulated in the short-storage arm. If a difference is found, this will indicate that fresher RBCs do improve outcomes in the pediatric intensive care unit population and would justify that use in critically ill children. If no difference is found, this will reassure clinicians and transfusion medicine specialists regarding the safety of the current system of allocating the oldest RBC unit in inventory and will discourage clinicians from preferentially requesting fresher blood for critically ill children. BACKGROUND: ClinicalTrials.gov, ID: NCT01977547 . Registered on 6 November 2013.Show less >
Show more >BACKGROUND: The "Age of Blood in Children in Pediatric Intensive Care Unit" (ABC PICU) study is a randomized controlled trial (RCT) that aims to determine if red blood cell (RBC) unit storage age affects outcomes in critically ill children. While RBCs can be stored for up to 42 days in additive solutions, their efficacy and safety after long-term storage have been challenged. Preclinical and clinical observational evidence suggests loss of efficacy and lack of safety of older RBC units, especially in more vulnerable populations such as critically ill children. Because there is a belief that shorter storage will improve outcomes, some physicians and institutions systematically transfuse fresh RBCs to children. Conversely, the standard practice of blood banks is to deliver the oldest available RBC unit (first-in, first-out policy) in order to decrease wastage. METHODS: The ABC PICU study, is a double-blind superiority trial comparing the development of "New or Progressive Multiple Organ Dysfunction Syndrome" (NPMODS) in 1538 critically ill children randomized to either transfusion with RBCs stored for ≤ 7 days or to standard-issue RBCs (oldest in inventory). Patients are being recruited from 52 centers in the US, Canada, France, Italy, and Israel. CONCLUSIONS: The ABC PICU study should have significant implications for blood procurement services. A relative risk reduction of 33% is postulated in the short-storage arm. If a difference is found, this will indicate that fresher RBCs do improve outcomes in the pediatric intensive care unit population and would justify that use in critically ill children. If no difference is found, this will reassure clinicians and transfusion medicine specialists regarding the safety of the current system of allocating the oldest RBC unit in inventory and will discourage clinicians from preferentially requesting fresher blood for critically ill children. BACKGROUND: ClinicalTrials.gov, ID: NCT01977547 . Registered on 6 November 2013.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Submission date :
2019-12-09T18:18:51Z
2020-05-28T13:45:24Z
2020-08-25T09:27:15Z
2020-05-28T13:45:24Z
2020-08-25T09:27:15Z
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