Outcome of 449 adult patients with ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
PMID :
URL permanente :
Titre :
Outcome of 449 adult patients with rhabdomyosarcoma: an observational ambispective nationwide study
Auteur(s) :
Bompas, Emmanuelle [Auteur]
CRLCC René Gauducheau
Campion, Loic [Auteur]
Centre René Gauducheau
Italiano, Antoine [Auteur]
Le Cesne, Axel [Auteur]
Institut Gustave Roussy [IGR]
Chevreau, Christine [Auteur]
Isambert, Nicolas [Auteur]
Département d'oncologie médicale [Centre Georges-François Leclerc]
Toulmonde, Maud [Auteur]
Mir, Olivier [Auteur]
Institut Gustave Roussy [IGR]
Ray-Coquard, Isabelle [Auteur]
Centre Léon Bérard [Lyon]
Piperno-Neumann, Sophie [Auteur]
Institut Curie [Paris]
Saada-Bouzid, Esma [Auteur]
Rios, Maria [Auteur]
Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] [UNICANCER/ICL]
Kurtz, Jean-Emmanuel [Auteur]
Les Hôpitaux Universitaires de Strasbourg (HUS)
Delcambre, Corinne [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Dubray-Longeras, Pascale [Auteur]
Centre Jean Perrin [Clermont-Ferrand] [UNICANCER/CJP]
Duffaud, Florence [Auteur]
CHU Marseille
Karanian, Marie [Auteur]
Centre Léon Bérard [Lyon]
Le Loarer, François [Auteur]
Soulie, Patrick [Auteur]
Institut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO]
Penel, Nicolas [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Blay, Jean-Yves [Auteur]
Centre Léon Bérard [Lyon]
CRLCC René Gauducheau
Campion, Loic [Auteur]
Centre René Gauducheau
Italiano, Antoine [Auteur]
Le Cesne, Axel [Auteur]
Institut Gustave Roussy [IGR]
Chevreau, Christine [Auteur]
Isambert, Nicolas [Auteur]
Département d'oncologie médicale [Centre Georges-François Leclerc]
Toulmonde, Maud [Auteur]
Mir, Olivier [Auteur]
Institut Gustave Roussy [IGR]
Ray-Coquard, Isabelle [Auteur]
Centre Léon Bérard [Lyon]
Piperno-Neumann, Sophie [Auteur]
Institut Curie [Paris]
Saada-Bouzid, Esma [Auteur]
Rios, Maria [Auteur]
Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] [UNICANCER/ICL]
Kurtz, Jean-Emmanuel [Auteur]
Les Hôpitaux Universitaires de Strasbourg (HUS)
Delcambre, Corinne [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Dubray-Longeras, Pascale [Auteur]
Centre Jean Perrin [Clermont-Ferrand] [UNICANCER/CJP]
Duffaud, Florence [Auteur]
CHU Marseille
Karanian, Marie [Auteur]
Centre Léon Bérard [Lyon]
Le Loarer, François [Auteur]
Soulie, Patrick [Auteur]
Institut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO]
Penel, Nicolas [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Blay, Jean-Yves [Auteur]
Centre Léon Bérard [Lyon]
Titre de la revue :
Cancer medicine
Nom court de la revue :
Cancer Med
Date de publication :
2018-06-28
ISSN :
2045-7634
Mot(s)-clé(s) en anglais :
pediatric
Adult cancer
rhabdomyosarcoma
Adult cancer
rhabdomyosarcoma
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a ...
Lire la suite >Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a large study. The study population consisted of two different cohorts: a retrospective cohort (157 adult patients treated in 13 reference centers between 05/1981 and 02/2010) and the prospective cohort (292 patients with RMS diagnosed and treated between 01/2010 and 12/2014 in France) included in the NetSarc database. A descriptive analysis of patients' characteristics and prognostic factors was conducted on both series which were compared. In the retrospective series, histological subtypes were embryonal (E-RMS) for 21% of patients, alveolar (A-RMS) for 35% of patients, and "adult-type" P-RMS (pleomorphic, spindle cell RMS, not otherwise specified) (P) for 44% patients. This distribution significantly differed in the prospective cohort: A-RMS: 18%; E-RMS: 17%; and P-RMS 65%. With a median follow-up of 8.5 years, 5-year OS for localized RMS and advanced RMS (with nodes and/or metastases) was 43% and 5%, respectively, (P < 0.0001), and median OS was 51, 33, and 16 months for E-RMS, A-RMS, and P-RMS, respectively, in the retrospective cohort. The median OS was less than 40 months for the prospective nationwide cohort for the entire population. In a multivariate analysis of the retrospective study, independent prognostic factors for OS were A-RMS, R0 resection, and adjuvant radiotherapy (RT). For localized RMS, age and use of pediatric chemotherapy (CT) regimen are independent prognostic factors. Adult patients with RMS have a poorer overall survival than pediatric patients, and survival varies considerably across histological subtypes.Lire moins >
Lire la suite >Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a large study. The study population consisted of two different cohorts: a retrospective cohort (157 adult patients treated in 13 reference centers between 05/1981 and 02/2010) and the prospective cohort (292 patients with RMS diagnosed and treated between 01/2010 and 12/2014 in France) included in the NetSarc database. A descriptive analysis of patients' characteristics and prognostic factors was conducted on both series which were compared. In the retrospective series, histological subtypes were embryonal (E-RMS) for 21% of patients, alveolar (A-RMS) for 35% of patients, and "adult-type" P-RMS (pleomorphic, spindle cell RMS, not otherwise specified) (P) for 44% patients. This distribution significantly differed in the prospective cohort: A-RMS: 18%; E-RMS: 17%; and P-RMS 65%. With a median follow-up of 8.5 years, 5-year OS for localized RMS and advanced RMS (with nodes and/or metastases) was 43% and 5%, respectively, (P < 0.0001), and median OS was 51, 33, and 16 months for E-RMS, A-RMS, and P-RMS, respectively, in the retrospective cohort. The median OS was less than 40 months for the prospective nationwide cohort for the entire population. In a multivariate analysis of the retrospective study, independent prognostic factors for OS were A-RMS, R0 resection, and adjuvant radiotherapy (RT). For localized RMS, age and use of pediatric chemotherapy (CT) regimen are independent prognostic factors. Adult patients with RMS have a poorer overall survival than pediatric patients, and survival varies considerably across histological subtypes.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Université de Lille
Université de Lille
Date de dépôt :
2019-12-09T18:18:57Z
2020-05-28T13:19:50Z
2020-05-28T13:19:50Z
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