Therapeutic body wraps (tbw) for treatment ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Therapeutic body wraps (tbw) for treatment of severe injurious behaviour in children with autism spectrum disorder (asd): a 3-month randomized controlled feasibility study
Auteur(s) :
Delion, Pierre [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Cohen, David [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Lallie, Celine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ravary, Maud [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Goeb, Jean-Louis [Auteur]
Medjkane, François [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Xavier, Jean [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Cohen, David [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Lallie, Celine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ravary, Maud [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Goeb, Jean-Louis [Auteur]
Medjkane, François [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Xavier, Jean [Auteur]
Titre de la revue :
PLoS One
Nom court de la revue :
PLoS ONE
Numéro :
13
Pagination :
e0198726
Date de publication :
2018-01-01
ISSN :
1932-6203
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The use of therapeutic body wraps (TBW) has been reported in small series or case reports, but has become controversial.
This is a feasibility, multicentre, randomized, controlled, open-label trial with blinded outcome ...
Lire la suite >The use of therapeutic body wraps (TBW) has been reported in small series or case reports, but has become controversial. This is a feasibility, multicentre, randomized, controlled, open-label trial with blinded outcome assessment (PROBE design). Children with autism and severe-injurious behaviours (SIB) were enrolled from 13 specialized clinics. Dry-sheet TBW (DRY group) vs. wet-sheet TBW (WET group). 3-month change in the Aberrant Behaviour Checklist irritability score (ABC-irritability) within per-protocol (PP) sample. From January 2008 to January 2015, we recruited 48 children (age range: 5.9 to 9.9 years, 78.1% male). Seven patients (4 in the DRY group, 3 in the WET group) were dropped from the study early and were excluded from PP analysis. At endpoint, ABC-irritability significantly improved in both groups (means (standard deviation) = -11.15 (8.05) in the DRY group and -10.57 (9.29) in the WET group), as did the other ABC scores and the Children Autism Rating scale score. However, there was no significant difference between groups. All but 5 patients were rated as much or very much improved. A repeated-measures analysis confirmed the significant improvement in ABC-irritability scores according to time (p < .0001), with no significant difference between the two groups (group effect: p = .55; interaction time x group: p = .27). Pooling both groups together, the mean 3-month change from baseline in ABC-irritability score was -10.90 (effect size = 1.59, p < .0001). We found that feasibility was overall satisfactory with a slow recruitment rate and a rather good attrition rate. TBW was a safe complementary therapy in this population. There was no difference between wet and dry TBW at 3 months, and ABC-irritability significantly decreased with both wet and dry sheet TBW. To assess whether TBW may constitute an alternative to medication or behavioural intervention for treating SIB in ASD patients, a larger randomized comparative trial (e.g. TBW vs. antipsychotics) is warranted. ClinicalTrials.gov NCT03164746.Lire moins >
Lire la suite >The use of therapeutic body wraps (TBW) has been reported in small series or case reports, but has become controversial. This is a feasibility, multicentre, randomized, controlled, open-label trial with blinded outcome assessment (PROBE design). Children with autism and severe-injurious behaviours (SIB) were enrolled from 13 specialized clinics. Dry-sheet TBW (DRY group) vs. wet-sheet TBW (WET group). 3-month change in the Aberrant Behaviour Checklist irritability score (ABC-irritability) within per-protocol (PP) sample. From January 2008 to January 2015, we recruited 48 children (age range: 5.9 to 9.9 years, 78.1% male). Seven patients (4 in the DRY group, 3 in the WET group) were dropped from the study early and were excluded from PP analysis. At endpoint, ABC-irritability significantly improved in both groups (means (standard deviation) = -11.15 (8.05) in the DRY group and -10.57 (9.29) in the WET group), as did the other ABC scores and the Children Autism Rating scale score. However, there was no significant difference between groups. All but 5 patients were rated as much or very much improved. A repeated-measures analysis confirmed the significant improvement in ABC-irritability scores according to time (p < .0001), with no significant difference between the two groups (group effect: p = .55; interaction time x group: p = .27). Pooling both groups together, the mean 3-month change from baseline in ABC-irritability score was -10.90 (effect size = 1.59, p < .0001). We found that feasibility was overall satisfactory with a slow recruitment rate and a rather good attrition rate. TBW was a safe complementary therapy in this population. There was no difference between wet and dry TBW at 3 months, and ABC-irritability significantly decreased with both wet and dry sheet TBW. To assess whether TBW may constitute an alternative to medication or behavioural intervention for treating SIB in ASD patients, a larger randomized comparative trial (e.g. TBW vs. antipsychotics) is warranted. ClinicalTrials.gov NCT03164746.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Date de dépôt :
2020-02-11T09:07:21Z
2020-03-27T10:53:45Z
2020-03-31T13:33:00Z
2020-03-27T10:53:45Z
2020-03-31T13:33:00Z
Fichiers
- Therapeutic body wraps (TBW).pdf
- Version éditeur
- Accès libre
- Accéder au document