Overview of Lactoferrin as a Natural Immune Modulator

Legrand, Dominique

Document type :

Article dans une revue scientifique

DOI :

10.1016/j.jpeds.2016.02.071

PMID :

27234406

Link :

https://lilloa.univ-lille.fr/handle/20.500.12210/18395

Title :

Overview of Lactoferrin as a Natural Immune Modulator

Author(s) :

Legrand, Dominique [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]

Journal title :

The Journal of pediatrics

Abbreviated title :

J. Pediatr.

Volume number :

173

Pages :

S10-15

Publication date :

2016-06

ISSN :

1097-6833

English keyword(s) :

Adaptive Immunity
Lactoferrin
Signal Transduction
Cytokines
Humans
Inflammation
Immunity, Innate

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Lactoferrin is thought to be the most polyvalent protein present in host defense against tissue injuries and infections in vertebrates. Owing to the propensity of its basic N-terminal domain to interact with various microbial ...
Show more >Lactoferrin is thought to be the most polyvalent protein present in host defense against tissue injuries and infections in vertebrates. Owing to the propensity of its basic N-terminal domain to interact with various microbial and host targets, lactoferrin not only has antimicrobial properties, but also modulates the innate and adaptive immune responses. Lactoferrin may indeed up- and downregulate immune cell activation, migration, and growth. Whereas the immunomodulatory properties of lactoferrin are evidenced from in vivo studies using either lactoferrin-knockout, lactoferrin-overexpressing transgenic models, and dietary lactoferrin, few mechanisms from in vitro studies have been proposed to explain these properties. The best characterized lactoferrin targets are negatively charged molecules. They encompass pro-inflammatory microbial molecules, such as pathogen-associated molecular patterns (eg, lipopolysaccharide), but also host components such as DNA, the glycosaminoglycan chains of proteoglycans, and surface cell receptors. Signaling through these receptors is thought to be the main lever used by lactoferrin to influence immune cells and cytokine-balance-controlling cell activity. This article aims to review our current understanding, though incomplete, of the many ways lactoferrin influences the complex immune machinery and the known and putative mechanisms that may explain its properties.Show less >

Language :

Anglais

Administrative institution(s) :

CNRS
Université de Lille

Collections :

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Mécanismes moléculaires de la N-glycosylation et pathologies associées

Submission date :

2020-02-12T15:12:00Z

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