Overview of Lactoferrin as a Natural Immune Modulator

Legrand, Dominique

Type de document :

Article dans une revue scientifique

DOI :

10.1016/j.jpeds.2016.02.071

PMID :

27234406

URL permanente :

http://hdl.handle.net/20.500.12210/18395

Titre :

Overview of Lactoferrin as a Natural Immune Modulator

Auteur(s) :

Legrand, Dominique [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]

Titre de la revue :

The Journal of pediatrics

Nom court de la revue :

J. Pediatr.

Numéro :

173

Pagination :

S10-15

Date de publication :

2016-06

ISSN :

1097-6833

Mot(s)-clé(s) en anglais :

Adaptive Immunity
Lactoferrin
Signal Transduction
Cytokines
Humans
Inflammation
Immunity, Innate

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

Lactoferrin is thought to be the most polyvalent protein present in host defense against tissue injuries and infections in vertebrates. Owing to the propensity of its basic N-terminal domain to interact with various microbial ...
Lire la suite >Lactoferrin is thought to be the most polyvalent protein present in host defense against tissue injuries and infections in vertebrates. Owing to the propensity of its basic N-terminal domain to interact with various microbial and host targets, lactoferrin not only has antimicrobial properties, but also modulates the innate and adaptive immune responses. Lactoferrin may indeed up- and downregulate immune cell activation, migration, and growth. Whereas the immunomodulatory properties of lactoferrin are evidenced from in vivo studies using either lactoferrin-knockout, lactoferrin-overexpressing transgenic models, and dietary lactoferrin, few mechanisms from in vitro studies have been proposed to explain these properties. The best characterized lactoferrin targets are negatively charged molecules. They encompass pro-inflammatory microbial molecules, such as pathogen-associated molecular patterns (eg, lipopolysaccharide), but also host components such as DNA, the glycosaminoglycan chains of proteoglycans, and surface cell receptors. Signaling through these receptors is thought to be the main lever used by lactoferrin to influence immune cells and cytokine-balance-controlling cell activity. This article aims to review our current understanding, though incomplete, of the many ways lactoferrin influences the complex immune machinery and the known and putative mechanisms that may explain its properties.Lire moins >

Langue :

Anglais

Établissement(s) :

CNRS
Université de Lille

Collections :

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Mécanismes moléculaires de la N-glycosylation et pathologies associées

Date de dépôt :

2020-02-12T15:12:00Z

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