Dual Effects of Hydrogen Sulfide Donor on ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
Dual Effects of Hydrogen Sulfide Donor on Meiosis and Cumulus Expansion of Porcine Cumulus-Oocyte Complexes
Auteur(s) :
Nevoral, Jan [Auteur]
Petr, Jaroslav [Auteur]
Gelaude, Armance [Auteur]
Laboratoire de Régulation des Signaux de Division
Bodart, Jean-Francois [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Kučerová-Chrpová, Veronika [Auteur]
Sedmikova, Marketa [Auteur]
Krejčová, Tereza [Auteur]
Kolbabova, Tereza [Auteur]
Dvořáková, Markéta [Auteur]
Vyskocilova, Alena [Auteur]
Weingartová, Ivona [Auteur]
Krivohlavkova, Lenka [Auteur]
Žalmanová, Tereza [Auteur]
Jílek, František [Auteur]
Petr, Jaroslav [Auteur]
Gelaude, Armance [Auteur]
Laboratoire de Régulation des Signaux de Division
Bodart, Jean-Francois [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Kučerová-Chrpová, Veronika [Auteur]
Sedmikova, Marketa [Auteur]
Krejčová, Tereza [Auteur]
Kolbabova, Tereza [Auteur]
Dvořáková, Markéta [Auteur]
Vyskocilova, Alena [Auteur]
Weingartová, Ivona [Auteur]
Krivohlavkova, Lenka [Auteur]
Žalmanová, Tereza [Auteur]
Jílek, František [Auteur]
Titre de la revue :
PLoS One
Numéro :
9
Pagination :
e99613
Date de publication :
2014-07-01
ISSN :
1932-6203
Mot(s)-clé(s) en anglais :
Oocytes
Meiosis
MAPK signaling cascades
Metaphase
Histones
Vesicles
Pipettes
Hydrogen
Meiosis
MAPK signaling cascades
Metaphase
Histones
Vesicles
Pipettes
Hydrogen
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Hydrogen sulfide (H2S) has been revealed to be a signal molecule with second messenger action in the somatic cells of many tissues, including the reproductive tract. The aim of this study was to address how exogenous H2S ...
Lire la suite >Hydrogen sulfide (H2S) has been revealed to be a signal molecule with second messenger action in the somatic cells of many tissues, including the reproductive tract. The aim of this study was to address how exogenous H2S acts on the meiotic maturation of porcine oocytes, including key maturation factors such as MPF and MAPK, and cumulus expansion intensity of cumulus-oocyte complexes. We observed that the H2S donor, Na2S, accelerated oocyte in vitro maturation in a dose-dependent manner, following an increase of MPF activity around germinal vesicle breakdown. Concurrently, the H2S donor affected cumulus expansion, monitored by hyaluronic acid production. Our results suggest that the H2S donor influences oocyte maturation and thus also participates in the regulation of cumulus expansion. The exogenous H2S donor apparently affects key signal pathways of oocyte maturation and cumulus expansion, resulting in faster oocyte maturation with little need of cumulus expansion.Lire moins >
Lire la suite >Hydrogen sulfide (H2S) has been revealed to be a signal molecule with second messenger action in the somatic cells of many tissues, including the reproductive tract. The aim of this study was to address how exogenous H2S acts on the meiotic maturation of porcine oocytes, including key maturation factors such as MPF and MAPK, and cumulus expansion intensity of cumulus-oocyte complexes. We observed that the H2S donor, Na2S, accelerated oocyte in vitro maturation in a dose-dependent manner, following an increase of MPF activity around germinal vesicle breakdown. Concurrently, the H2S donor affected cumulus expansion, monitored by hyaluronic acid production. Our results suggest that the H2S donor influences oocyte maturation and thus also participates in the regulation of cumulus expansion. The exogenous H2S donor apparently affects key signal pathways of oocyte maturation and cumulus expansion, resulting in faster oocyte maturation with little need of cumulus expansion.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
CNRS
Université de Lille
Université de Lille
Équipe(s) de recherche :
Régulation des signaux de division
Date de dépôt :
2020-02-12T15:44:32Z
2021-01-08T07:56:09Z
2021-01-08T07:56:09Z
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