Structurally Flexible Triethanolamine Core ...
Document type :
Article dans une revue scientifique: Article original
DOI :
Permalink :
Title :
Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus
Author(s) :
Liu, Xiaoxuan [Auteur]
Wu, Jiangyu [Auteur]
Yammine, Miriam [Auteur]
Technologies avancées pour le génôme et la clinique [TAGC]
Zhou, Jiehua [Auteur]
Posocco, Paola [Auteur]
Viel, Stéphane [Auteur]
Institut de Chimie Radicalaire [ICR]
Liu, Cheng [Auteur]
Ziarelli, Fabio [Auteur]
Fermeglia, Maurizio [Auteur]
Pricl, Sabrina [Auteur]
Victorero, Genevieve [Auteur]
Technologies avancées pour le génôme et la clinique [TAGC]
Nguyen, Catherine [Auteur]
Technologies avancées pour le génôme et la clinique [TAGC]
Erbacher, Patrick [Auteur]
Behr, Jean-Paul [Auteur]
Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
Laboratoire de chimie bioorganique [LCB]
Peng, Ling [Auteur]
Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 [L2EP]
Wu, Jiangyu [Auteur]
Yammine, Miriam [Auteur]
Technologies avancées pour le génôme et la clinique [TAGC]
Zhou, Jiehua [Auteur]
Posocco, Paola [Auteur]
Viel, Stéphane [Auteur]
Institut de Chimie Radicalaire [ICR]
Liu, Cheng [Auteur]
Ziarelli, Fabio [Auteur]
Fermeglia, Maurizio [Auteur]
Pricl, Sabrina [Auteur]
Victorero, Genevieve [Auteur]
Technologies avancées pour le génôme et la clinique [TAGC]
Nguyen, Catherine [Auteur]
Technologies avancées pour le génôme et la clinique [TAGC]
Erbacher, Patrick [Auteur]
Behr, Jean-Paul [Auteur]
Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
Laboratoire de chimie bioorganique [LCB]
Peng, Ling [Auteur]
Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 [L2EP]
Journal title :
Bioconjugate Chemistry
Volume number :
22
Pages :
2461--2473
Publisher :
American Chemical Society
Publication date :
2011-12
ISSN :
1043-1802
English keyword(s) :
Rodent models
Gene delivery
Genetics
Dendrons
Molecules
Gene delivery
Genetics
Dendrons
Molecules
HAL domain(s) :
Chimie
English abstract : [en]
With the aim of developing dendrimer nanovectors with a precisely controlled architecture and flexible structure for DNA transfection, we designed PAMAM dendrimers bearing a triethanolamine (TEA) core, with branching units ...
Show more >With the aim of developing dendrimer nanovectors with a precisely controlled architecture and flexible structure for DNA transfection, we designed PAMAM dendrimers bearing a triethanolamine (TEA) core, with branching units pointing away from the center to create void spaces, reduce steric congestion, and increase water accessibility for the benefit of DNA delivery. These dendrimers are shown to form stable nanoparticles with DNA, promote cell uptake mainly via macropinocytosis, and act as effective nanovectors for DNA transfection in vitro on epithelial and fibroblast cells and, most importantly, in vivo in the mouse thymus, an exceedingly challenging organ for immune gene therapy. Collectively, these results validate our rational design approach of structurally flexible dendrimers with a chemically defined structure as effective nanovectors for gene delivery, and demonstrate the potential of these dendrimers in intrathymus gene delivery for future applications in immune gene therapy.Show less >
Show more >With the aim of developing dendrimer nanovectors with a precisely controlled architecture and flexible structure for DNA transfection, we designed PAMAM dendrimers bearing a triethanolamine (TEA) core, with branching units pointing away from the center to create void spaces, reduce steric congestion, and increase water accessibility for the benefit of DNA delivery. These dendrimers are shown to form stable nanoparticles with DNA, promote cell uptake mainly via macropinocytosis, and act as effective nanovectors for DNA transfection in vitro on epithelial and fibroblast cells and, most importantly, in vivo in the mouse thymus, an exceedingly challenging organ for immune gene therapy. Collectively, these results validate our rational design approach of structurally flexible dendrimers with a chemically defined structure as effective nanovectors for gene delivery, and demonstrate the potential of these dendrimers in intrathymus gene delivery for future applications in immune gene therapy.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Comment :
https://hal.archives-ouvertes.fr/hal-01460316
Submission date :
2020-05-15T13:48:40Z
2022-02-16T09:34:39Z
2022-02-16T09:34:39Z