Title :

Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence

Author(s) :

Nocera, Sonia [Auteur]
Centre de Psychiatrie et Neurosciences [U894]
Simon, Axelle [Auteur]
Centre de Psychiatrie et Neurosciences [U894]
Fiquet, Oriane [Auteur]
Centre de Psychiatrie et Neurosciences [U894]
Chen, Ying [Auteur]
Centre de Psychiatrie et Neurosciences [U894]
Gascuel, Jean [Auteur]
Centre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
Datiche, Frédérique [Auteur]
Centre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
Schneider, Nanette [Auteur]
Centre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
Epelbaum, Jacques [Auteur]
Centre de Psychiatrie et Neurosciences [U894]
Viollet, Cécile [Auteur]
Centre de Psychiatrie et Neurosciences [U894]

Journal title :

Frontiers in Behavioral Neuroscience

Pages :

61

Publisher :

Frontiers

Publication date :

2019

ISSN :

1662-5153

English keyword(s) :

SSTR4
SSTR2
SSTR3
knockout mice
somatostatin receptor
mitral cells
interneurons
olfaction

HAL domain(s) :

Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie

English abstract : [en]

Somatostatin (SOM) and somatostatin receptors (SSTR1-4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses. ...
Show more >Somatostatin (SOM) and somatostatin receptors (SSTR1-4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses. In this work, histological, viral tracing and transgenic approaches were used to characterize SOM cellular targets in the murine OB. We demonstrate that SOM targets all levels of mitral dendritic processes in the OB with somatostatin receptor 2 (SSTR2) detected in the dendrites of previously uncharacterized mitral-like cells. We show that inhibitory interneurons of the glomerular layer (GL) express SSTR4 while SSTR3 is confined to the granule cell layer (GCL). Furthermore, SOM cells in the OB receive synaptic inputs from olfactory cortical afferents. Behavioral studies demonstrate that genetic deletion of SSTR4, SSTR2 or SOM differentially affects olfactory performance. SOM or SSTR4 deletion have no major effect on olfactory behavioral performances while SSTR2 deletion impacts olfactory detection and discrimination behaviors. Altogether, these results describe novel anatomical and behavioral contributions of SOM, SSTR2 and SSTR4 receptors in olfactory processing.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Le déficit somatostatinergique dans le système olfactif : biomarqueur précoce de la maladie d'Alzheimer

Comment :

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fnbeh.2019.00061/full#supplementary-material PMCID: PMC6465642

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL