Title :

Structure function analysis of Leishmania sirtuin: an ensemble of in silico and biochemical studies.

Author(s) :

Kadam, Rameshwar U [Auteur]
National Institute of Pharmaceutical Education and Research [NIPER]
Tavares, Joana [Auteur]
Laboratoire Leibniz [Leibniz - IMAG]
Kiran, V. M. [Auteur]
National Institute of Pharmaceutical Education and Research [NIPER]
Cordeiro, Anabela [Auteur]
Universidade do Porto = University of Porto
Ouaissi, Ali [Auteur]
UR008 Pathogénie des Trypanosomatidés [IRD]
Dynamique des interactions membranaires normales et pathologiques [DIMNP]
Roy, Nilanjan [Auteur]
National Institute of Pharmaceutical Education and Research [NIPER]
Institut Fourier [IF]

Journal title :

Chemical Biology and Drug Design

Pages :

501-6

Publisher :

Wiley

Publication date :

2008-05

ISSN :

1747-0277

HAL domain(s) :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire

English abstract : [en]

Novel anti-leishmanial target LmSir2 has few subtle but prudent structural differences in ligand binding and catalytic domain as compared to its human counterpart. In silico screening and validation followed by in vitro ...
Show more >Novel anti-leishmanial target LmSir2 has few subtle but prudent structural differences in ligand binding and catalytic domain as compared to its human counterpart. In silico screening and validation followed by in vitro deacetylation and cell killing assays described herein give a proof of concept for development of strategies exploiting such minor differences for screening libraries of small molecules to identify selective inhibitors.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL