An ecological approach to discover new ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
An ecological approach to discover new bioactive extracts and products: the case of extremophile plants
Auteur(s) :
Sahli, Ramla [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Rivière, Céline [Auteur correspondant]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Neut, Christel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bero, Joanne [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Sahuc, Marie-Emmanuelle [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Smaoui, Abderrazak [Auteur]
Laboratoire des plantes aromatiques et médicinales (Faculté des Sciences Mathématiques, Physiques et Naturelles, Tunis) [LPAM]
Beaufay, Claire [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Roumy, Vincent [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Hennebelle, Thierry [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Rouillé, Yves [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Quetin-Leclercq, Joëlle [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Seron, Karin [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Ksouri, Riadh [Auteur]
Laboratoire des plantes aromatiques et médicinales (Faculté des Sciences Mathématiques, Physiques et Naturelles, Tunis) [LPAM]
Sahpaz, Sevser [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Rivière, Céline [Auteur correspondant]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Neut, Christel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bero, Joanne [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Sahuc, Marie-Emmanuelle [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Smaoui, Abderrazak [Auteur]
Laboratoire des plantes aromatiques et médicinales (Faculté des Sciences Mathématiques, Physiques et Naturelles, Tunis) [LPAM]
Beaufay, Claire [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Roumy, Vincent [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Hennebelle, Thierry [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Rouillé, Yves [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Quetin-Leclercq, Joëlle [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Seron, Karin [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Ksouri, Riadh [Auteur]
Laboratoire des plantes aromatiques et médicinales (Faculté des Sciences Mathématiques, Physiques et Naturelles, Tunis) [LPAM]
Sahpaz, Sevser [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Titre de la revue :
Journal of Pharmacy and Pharmacology
Pagination :
1041-1055
Éditeur :
Royal Pharmaceutical Society of Great Britain
Date de publication :
2017-08
ISSN :
0022-3573
Mot(s)-clé(s) en anglais :
antibacterial activity
antiradical activity
antiviral activity
cytotoxic activity
extremophile plants
antiradical activity
antiviral activity
cytotoxic activity
extremophile plants
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
OBJECTIVES:Eight extremophile plants from Tunisia were screened to find natural products with benefits in human health.METHODS:These plants were collected in different areas in Tunisia. Their methanolic extracts were ...
Lire la suite >OBJECTIVES:Eight extremophile plants from Tunisia were screened to find natural products with benefits in human health.METHODS:These plants were collected in different areas in Tunisia. Their methanolic extracts were evaluated for their total phenolic content and for their antiradical (DPPH), antimicrobial (on 35 bacteria and one yeast), antiviral (hepatitis C virus, HCV) and cytotoxic activity (against WI38 and J774 cell lines). The most active species were subjected to a bioguided fractionation.KEY FINDINGS:The screening revealed promising activity for four plants, but two species have both antiradical and antimicrobial activity: Juncus maritimus and Limonium virgatum. The rhizomes extract of J. maritimus showed the highest activity against HCV, a selective antibacterial activity against Streptococcus dysgalactiae, and a moderate antiradical activity which is due to luteolin isolated in one step by centrifugal partition chromatography. The stems' and leaves' extracts of L. virgatum were rich in polyphenols responsible for the antiradical activity. Also, Limonium extracts showed an antibacterial activity with a broad spectrum.CONCLUSIONS:Extremophile plants have proven to be a promising source for bioactive metabolites. They have a powerful antioxidant system highly influenced by biotic and abiotic factors and the ability to produce secondary metabolites with antimicrobial activityLire moins >
Lire la suite >OBJECTIVES:Eight extremophile plants from Tunisia were screened to find natural products with benefits in human health.METHODS:These plants were collected in different areas in Tunisia. Their methanolic extracts were evaluated for their total phenolic content and for their antiradical (DPPH), antimicrobial (on 35 bacteria and one yeast), antiviral (hepatitis C virus, HCV) and cytotoxic activity (against WI38 and J774 cell lines). The most active species were subjected to a bioguided fractionation.KEY FINDINGS:The screening revealed promising activity for four plants, but two species have both antiradical and antimicrobial activity: Juncus maritimus and Limonium virgatum. The rhizomes extract of J. maritimus showed the highest activity against HCV, a selective antibacterial activity against Streptococcus dysgalactiae, and a moderate antiradical activity which is due to luteolin isolated in one step by centrifugal partition chromatography. The stems' and leaves' extracts of L. virgatum were rich in polyphenols responsible for the antiradical activity. Also, Limonium extracts showed an antibacterial activity with a broad spectrum.CONCLUSIONS:Extremophile plants have proven to be a promising source for bioactive metabolites. They have a powerful antioxidant system highly influenced by biotic and abiotic factors and the ability to produce secondary metabolites with antimicrobial activityLire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :