Title :

The Biology and Epidemiology of Mycobacterium canettii

Author(s) :

Supply, Philip [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Brosch, Roland [Auteur correspondant]
Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics

Scientific editor(s) :

Sebastien Gagneux

Book title :

Strain Variation in the Mycobacterium tuberculosis Complex:Its Role in Biology, Epidemiology and Control

Publisher :

Springer

Publication date :

2017-11-08

ISBN :

978-3-319-64371-7

English keyword(s) :

Progenitor
Smooth colony morphology
Virulence
Evolution
Mycobacterium tuberculosis
Phylogeny

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Biologie cellulaire/Interactions cellulaires [q-bio.CB]
Sciences du Vivant [q-bio]/Génétique/Génétique humaine
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie

English abstract : [en]

Genome-based insights into the evolution of Mycobacterium tuberculosis and other tuberculosis-causing mycobacteria are constantly increasing. In particular, the recent genomic and functional characterization of several ...
Show more >Genome-based insights into the evolution of Mycobacterium tuberculosis and other tuberculosis-causing mycobacteria are constantly increasing. In particular, the recent genomic and functional characterization of several Myocbacterium canettii strains, which are thought to resemble in many aspects the putative common ancestor of the members of the M. tuberculosis complex (MTBC), has consolidated a plausible scenario of the early evolution of tuberculosis-causing mycobacteria, in which the clonal MTBC, comprising numerous key pathogens of mammalian hosts, has evolved from a generalist mycobacterium living in the environment. These studies also have considerably enriched our knowledge on selected molecular events that likely have contributed to the incursion, maintenance and spread of the MTBC members in diverse mammalian hosts. Here, we summarize and discuss recently revealed molecular and evolutionary aspects and emphasize the vast utility of M. canettii strains for identifying the mechanisms that contributed to the global emergence of M. tuberculosis as one of the most important human pathogens.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

European Project :

TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL