Compartmentalized Antimicrobial Defenses ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
Compartmentalized Antimicrobial Defenses in Response to Flagellin
Auteur(s) :
Vijayan, Aneesh [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Rumbo, Martin [Auteur]
Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] [CONICET]
Universidad Nacional de la Plata [Argentine] [UNLP]
Carnoy, Christophe [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
SIRARD, Jean-Claude [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Rumbo, Martin [Auteur]
Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] [CONICET]
Universidad Nacional de la Plata [Argentine] [UNLP]
Carnoy, Christophe [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
SIRARD, Jean-Claude [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Titre de la revue :
Trends in microbiology
Pagination :
143 - 153
Éditeur :
Elsevier
Date de publication :
2017-11
ISSN :
0966-842X
Mot(s)-clé(s) :
Phagocytosis
polymorphonuclear leukocytes
recruitment
Mycobacterium boris (BCG)
polymorphonuclear leukocytes
recruitment
Mycobacterium boris (BCG)
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Résumé :
Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella constitute the machinery that propels bacteria into appropriate niches. Besides motility, the structural component, flagellin, ...
Lire la suite >Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella constitute the machinery that propels bacteria into appropriate niches. Besides motility, the structural component, flagellin, which forms the flagella, targets Toll-like receptor 5 (TLR5) to activate innate immunity. The compartmentalization of flagellin-mediated immunity and the contribution of epithelial cells and dendritic cells in detecting flagellin within luminal and basal sides are highlighted here, respectively. While a direct stimulation of the epithelium mainly results in recruitment of immune cells and production of antimicrobial molecules, TLR5 engagement on parenchymal dendritic cells can contribute to the stimulation of innate lymphocytes such as type 3 innate lymphoid cells, as well as T helper cells. This review, therefore, illustrates how the innate and adaptive immunity to flagellin are differentially regulated by the epithelium and the dendritic cells in response to pathogens that either colonize or invade mucosa.Lire moins >
Lire la suite >Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella constitute the machinery that propels bacteria into appropriate niches. Besides motility, the structural component, flagellin, which forms the flagella, targets Toll-like receptor 5 (TLR5) to activate innate immunity. The compartmentalization of flagellin-mediated immunity and the contribution of epithelial cells and dendritic cells in detecting flagellin within luminal and basal sides are highlighted here, respectively. While a direct stimulation of the epithelium mainly results in recruitment of immune cells and production of antimicrobial molecules, TLR5 engagement on parenchymal dendritic cells can contribute to the stimulation of innate lymphocytes such as type 3 innate lymphoid cells, as well as T helper cells. This review, therefore, illustrates how the innate and adaptive immunity to flagellin are differentially regulated by the epithelium and the dendritic cells in response to pathogens that either colonize or invade mucosa.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Projet Européen :
Source :
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- https://www.hal.inserm.fr/inserm-01671191/document
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- http://www.hal.inserm.fr/inserm-01671191/file/Manuscript_TIM2017_AV_revision_201017.pdf
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