Title :

Ester prodrugs of ciprofloxacin as DNA-gyrase inhibitors: Synthesis, antiparasitic evaluation and docking studies

Author(s) :

Dubar, Faustine [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Wintjens, René [Auteur]
Martins-Duarte, E. [Auteur]
Laboratório de Ultraestrutura Celular Hertha Meyer - IBCCF / UFRJ [Rio de Janeiro]
Vommaro, R. [Auteur]
Laboratório de Ultraestrutura Celular Hertha Meyer - IBCCF / UFRJ [Rio de Janeiro]
de Souza, W. [Auteur]
Laboratório de Ultraestrutura Celular Hertha Meyer - IBCCF / UFRJ [Rio de Janeiro]
Dive, Daniel [Auteur]
Schistosomiase, paludisme et inflammation
Pierrot, C. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pradines, Bruno [Auteur]
Unité de Recherche en Biologie et Epidémiologie Parasitaires
Wohlkönig, A. [Auteur]
Khalife, Jamal [Auteur]
Schistosomiase, paludisme et inflammation
Biot, Christophe [Auteur correspondant]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]

Journal title :

MedChemComm

Pages :

430-435

Publisher :

Royal Society of Chemistry

Publication date :

2011-05

ISSN :

2040-2503

HAL domain(s) :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]

English abstract : [en]

Novel ester prodrugs of ciprofloxacin were synthesized, and tested for their antimalarial and antitoxoplasma activity. These new compounds proved to be extremely efficient against these parasites. Molecular modeling and ...
Show more >Novel ester prodrugs of ciprofloxacin were synthesized, and tested for their antimalarial and antitoxoplasma activity. These new compounds proved to be extremely efficient against these parasites. Molecular modeling and computational calculations were used to understand the mechanisms of action of these drugs.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL