The neural correlates of the visual ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
The neural correlates of the visual consciousness in schizophrenia: an fMRI study.
Auteur(s) :
Lefebvre, S [Auteur]
Very, E [Auteur]
Jardri, R [Auteur]
Horn, M [Auteur]
Yrondi, A [Auteur]
Delmaire, C [Auteur]
Rascle, C [Auteur]
Dujardin, K [Auteur]
Thomas, P [Auteur]
Pins, D [Auteur]
Very, E [Auteur]
Jardri, R [Auteur]
Horn, M [Auteur]
Yrondi, A [Auteur]
Delmaire, C [Auteur]
Rascle, C [Auteur]
Dujardin, K [Auteur]
Thomas, P [Auteur]
Pins, D [Auteur]
Titre de la revue :
European Archives of Psychiatry and Clinical Neuroscience
Nom court de la revue :
Eur Arch Psychiatry Clin Neurosci
Éditeur :
Springer
Date de publication :
2020-08-19
ISSN :
1433-8491
Mot(s)-clé(s) en anglais :
Anterior cingulate cortex
Conscious visual processing
Consciousness disorder
Schizophrenia
Unconscious visual processing
fMRI
Conscious visual processing
Consciousness disorder
Schizophrenia
Unconscious visual processing
fMRI
Discipline(s) HAL :
Sciences cognitives/Neurosciences
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentale
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentale
Résumé en anglais : [en]
In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, ...
Lire la suite >In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, when the second model suggests that consciousness disorders rely on disruption in the ability to consciously access information, with preserved unconscious processing. The current study aims to understand the mechanisms associated with visual consciousness disorder in order to pave the road that will settle the debate regarding these hypotheses. During a functional magnetic resonance imaging session, 19 healthy participants (HC) and 15 patients with schizophrenia (SCZ) performed a visual detection task to compare the neural substrates associated with the conscious access to the visual inputs. The visual detection threshold was significantly higher in SCZ than in HC [t(32) = 3.37, p = 0.002]. Whole-brain ANOVA demonstrated that around the visual detection threshold patients with SCZ failed to activate a large network of brain areas compared to HC. (1) During conscious vision, HC engaged more the left cuneus and the right occipital cortex than patients with SCZ, (2) during unconscious vision, HC engaged a large network that patients with SCZ failed to activate, and finally, (3) during the access to consciousness process, patients with SCZ failed to activate the anterior cingulate cortex. These results suggest that the consciousness disorders in schizophrenia rely on specific dysfunctions depending on the consciousness stage. The disorders of the conscious vision are associated with dysfunction of occipital areas while the ones associated with unconscious vision rely on a large widespread network. Finally, the conscious access to the visual inputs is impaired by a dysfunction of the anterior cingulate cortex. The current study suggests that none of the two suggested models can explain consciousness disorders in schizophrenia. We suggest that there is an alternative model supporting that the conscious access to visual inputs is due to a disengagement of the supragenual anterior cingulate during the unconscious processing of the visual inputs associated with a sensory deficit.Lire moins >
Lire la suite >In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, when the second model suggests that consciousness disorders rely on disruption in the ability to consciously access information, with preserved unconscious processing. The current study aims to understand the mechanisms associated with visual consciousness disorder in order to pave the road that will settle the debate regarding these hypotheses. During a functional magnetic resonance imaging session, 19 healthy participants (HC) and 15 patients with schizophrenia (SCZ) performed a visual detection task to compare the neural substrates associated with the conscious access to the visual inputs. The visual detection threshold was significantly higher in SCZ than in HC [t(32) = 3.37, p = 0.002]. Whole-brain ANOVA demonstrated that around the visual detection threshold patients with SCZ failed to activate a large network of brain areas compared to HC. (1) During conscious vision, HC engaged more the left cuneus and the right occipital cortex than patients with SCZ, (2) during unconscious vision, HC engaged a large network that patients with SCZ failed to activate, and finally, (3) during the access to consciousness process, patients with SCZ failed to activate the anterior cingulate cortex. These results suggest that the consciousness disorders in schizophrenia rely on specific dysfunctions depending on the consciousness stage. The disorders of the conscious vision are associated with dysfunction of occipital areas while the ones associated with unconscious vision rely on a large widespread network. Finally, the conscious access to the visual inputs is impaired by a dysfunction of the anterior cingulate cortex. The current study suggests that none of the two suggested models can explain consciousness disorders in schizophrenia. We suggest that there is an alternative model supporting that the conscious access to visual inputs is due to a disengagement of the supragenual anterior cingulate during the unconscious processing of the visual inputs associated with a sensory deficit.Lire moins >
Comité de lecture :
Oui
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2020-10-02T10:55:51Z