Title :

Infections and cancer: the "fifty shades of immunity" hypothesis

Author(s) :

Jacqueline, Camille [Auteur]
Génétique et évolution des maladies infectieuses [GEMI]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Tasiemski, Aurélie [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Sorci, Gabriele [Auteur]
Biogéosciences [UMR 6282] [BGS]
Ujvari, Beata [Auteur]
Maachi, Fatima [Auteur]
Missé, Dorothée [Auteur]
Génétique et évolution des maladies infectieuses [GEMI]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Renaud, François [Auteur]
Génétique et évolution des maladies infectieuses [GEMI]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Ewald, Paul [Auteur]
Thomas, Frédéric [Auteur]
Génétique et évolution des maladies infectieuses [GEMI]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Roche, Benjamin [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] [UMMISCO]

Journal title :

BMC Cancer

Pages :

257

Publisher :

BioMed Central

Publication date :

2017

ISSN :

1471-2407

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Immunologie

English abstract : [en]

Background: Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have also ...
Show more >Background: Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have also attracted considerable interest as possible agents of tumor destruction.Discussion: Lost in the dichotomy between oncogenic and oncolytic agents, the indirect influence of infectious organisms on carcinogenesis has been largely unexplored. We describe the various ways – from functional aspects to evolutionary considerations such as modernity mismatches – by which infectious organisms could interfere with oncogenic processes through immunity. Finally, we discuss how acknowledging these interactions might impact public health approaches and suggest new guidelines for therapeutic and preventive strategies both at individual and population levels.Summary: Infectious organisms, that are not oncogenic neither oncolytic, may play a significant role in carcinogenesis, suggesting the need to increase our knowledge about immune interactions between infections and cancer.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198

Source :

Harvested from HAL