A case-comparison study of executive ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
A case-comparison study of executive functions in alcohol-dependent adults with maternal history of alcoholism
Auteur(s) :
Cottencin, Olivier [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Nandrino, Jean-Louis [Auteur]
Unité de Recherche en Sciences Cognitives et Affectives [URECA]
Karila, Laurent [Auteur]
Hôpital Paul Brousse
Mezerette, Caroline [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Danel, Thierry [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Faculté de Médecine Henri Warembourg - Université de Lille
Nandrino, Jean-Louis [Auteur]
Unité de Recherche en Sciences Cognitives et Affectives [URECA]
Karila, Laurent [Auteur]
Hôpital Paul Brousse
Mezerette, Caroline [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Danel, Thierry [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Titre de la revue :
European Psychiatry
Nom court de la revue :
Eur. psychiatr.
Numéro :
24
Pagination :
p. 195-200
Éditeur :
Cambridge University Press (CUP)
Date de publication :
2009-04
Mot(s)-clé(s) en anglais :
Alcohol dependence
Maternal history of alcoholism
Prenatal alcohol exposure
Executive function disorders
Maternal history of alcoholism
Prenatal alcohol exposure
Executive function disorders
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
Introduction: As executive dysfunctions frequently accompany alcohol dependence, we suggest that reports of executive dysfunction in alcoholics are actually due, in some case to a maternal history of alcohol misuse (MHA+). ...
Lire la suite >Introduction: As executive dysfunctions frequently accompany alcohol dependence, we suggest that reports of executive dysfunction in alcoholics are actually due, in some case to a maternal history of alcohol misuse (MHA+). A history of maternal alcohol dependence increases the risk for prenatal alcohol exposure to unborn children. These exposures likely contribute to executive dysfunction in adult alcoholics. To assess this problem, we propose a case-comparison study of alcohol-dependent subjects with and without a MHA. Methods: Ten alcohol-dependent subjects, with a maternal history of alcoholism (MHA) and paternal history of alcoholism (PHA), were matched with 10 alcohol-dependent people with only a paternal history of alcoholism (PHA). Executive functions (cancellation, Stroop, and trail-making A and B tests) and the presence of a history of three mental disorders (attention deficit hyperactivity disorder, violent behavior while intoxicated, and suicidal behavior) were evaluated in both populations. Results: Alcohol-dependent subjects with MHA showed a significant alteration in executive functions and significantly more disorders related to these functions than PHA subjects. The major measures of executive functioning deficit are duration on task accomplishment in all tests. Rates of ADHD and suicidality were found to be higher in MHA patients compared to the controls. Conclusion: A history of MHA, because of the high risk of PAE (in spite of the potential confounding factors such as environment) must be scrupulously documented when evaluating mental and cognitive disorders in a general population of alcoholics to ensure a better identification of these disorders. It would be helpful to replicate the study with more subjects.Lire moins >
Lire la suite >Introduction: As executive dysfunctions frequently accompany alcohol dependence, we suggest that reports of executive dysfunction in alcoholics are actually due, in some case to a maternal history of alcohol misuse (MHA+). A history of maternal alcohol dependence increases the risk for prenatal alcohol exposure to unborn children. These exposures likely contribute to executive dysfunction in adult alcoholics. To assess this problem, we propose a case-comparison study of alcohol-dependent subjects with and without a MHA. Methods: Ten alcohol-dependent subjects, with a maternal history of alcoholism (MHA) and paternal history of alcoholism (PHA), were matched with 10 alcohol-dependent people with only a paternal history of alcoholism (PHA). Executive functions (cancellation, Stroop, and trail-making A and B tests) and the presence of a history of three mental disorders (attention deficit hyperactivity disorder, violent behavior while intoxicated, and suicidal behavior) were evaluated in both populations. Results: Alcohol-dependent subjects with MHA showed a significant alteration in executive functions and significantly more disorders related to these functions than PHA subjects. The major measures of executive functioning deficit are duration on task accomplishment in all tests. Rates of ADHD and suicidality were found to be higher in MHA patients compared to the controls. Conclusion: A history of MHA, because of the high risk of PAE (in spite of the potential confounding factors such as environment) must be scrupulously documented when evaluating mental and cognitive disorders in a general population of alcoholics to ensure a better identification of these disorders. It would be helpful to replicate the study with more subjects.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Collections :
Date de dépôt :
2020-12-30T17:24:36Z
2021-01-12T10:42:21Z
2021-01-12T10:42:21Z
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- Cottencin et al 2009.pdf
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