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Real-Time Molecular Diagnosis of Tumors ...
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Document type :
Article dans une revue scientifique
DOI :
10.1016/j.ccell.2018.09.009
PMID :
30344004
Title :
Real-Time Molecular Diagnosis of Tumors Using Water-Assisted Laser Desorption/Ionization Mass Spectrometry Technology
Author(s) :
Saudemont, Philippe [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Quanico, Jusal [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Robin, Yves-Marie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Baud, Anna [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Balog, Julia [Auteur]
Imperial College London
Fatou, Benoit [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Tierny, Dominique [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Pascal, Quentin [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Minier, Kevin [Auteur]
Pottier, Mélissa [Auteur]
Focsa, Cristian [Auteur] refId
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Ziskind, Michael [Auteur] refId
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Takats, Zoltan [Auteur]
Imperial College London
Salzet, Michel [Auteur] refId
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
FOURNIER, Isabelle [Auteur correspondant] orcid refId
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Journal title :
Cancer Cell
Pages :
840-851.e4
Publisher :
Elsevier
Publication date :
2018-11
ISSN :
1535-6108
English keyword(s) :
SpiderMass
ambient ionization mass spectrometry
cancer
diagnostic
laser microprobe
molecular signatures
non-invasive
real time
sarcoma
surgery.
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Histopathological diagnosis of biopsy samples and margin assessment of surgical specimens are challenging aspects in sarcoma. Using dog patient tissues, we assessed the performance of a recently developed technology for ...
Show more >
Histopathological diagnosis of biopsy samples and margin assessment of surgical specimens are challenging aspects in sarcoma. Using dog patient tissues, we assessed the performance of a recently developed technology for fast ex vivo molecular lipid-based diagnosis of sarcomas. The instrument is based on mass spectrometry (MS) molecular analysis through a laser microprobe operating under ambient conditions using excitation of endogenous water molecules. Classification models based on cancer/normal/necrotic, tumor grade, and subtypes showed a minimum of 97.63% correct classification. Specific markers of normal, cancer, and necrotic regions were identified by tandem MS and validated by MS imaging. Real-time detection capabilities were demonstrated by ex vivo analysis with direct interrogation of classification models.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
  • Laboratoire de Physique des Lasers, Atomes et Molécules (PhLAM) - UMR 8523
Source :
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