Airway administration of flagellin regulates ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa
Auteur(s) :
López-Gálvez, Raquel [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Fleurot, Isabelle []
Infectiologie et Santé Publique [UMR ISP]
Chamero, Pablo [Auteur]
Physiologie de la reproduction et des comportements [Nouzilly] [PRC]
Trapp, Sascha [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Michel, Olivier [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Chevaleyre, Claire [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Barc, Céline [Auteur]
Plateforme d'Infectiologie Expérimentale [PFIE]
Riou, Mickael [Auteur]
Plateforme d'Infectiologie Expérimentale [PFIE]
Rossignol, Christelle [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Guillon, Antoine [Auteur]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
Si-Tahar, Mustapha [Auteur]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
May, Tobias [Auteur]
Barbry, Pascal [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Bähr, Andrea [Auteur]
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
Klymiuk, Nikolai [Auteur]
Sirard, Jean-Claude [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Caballero, Ignacio [Auteur correspondant]
Infectiologie et Santé Publique [UMR ISP]
Infectiologie et Santé Publique [UMR ISP]
Fleurot, Isabelle []
Infectiologie et Santé Publique [UMR ISP]
Chamero, Pablo [Auteur]
Physiologie de la reproduction et des comportements [Nouzilly] [PRC]
Trapp, Sascha [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Michel, Olivier [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Chevaleyre, Claire [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Barc, Céline [Auteur]
Plateforme d'Infectiologie Expérimentale [PFIE]
Riou, Mickael [Auteur]
Plateforme d'Infectiologie Expérimentale [PFIE]
Rossignol, Christelle [Auteur]
Infectiologie et Santé Publique [UMR ISP]
Guillon, Antoine [Auteur]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
Si-Tahar, Mustapha [Auteur]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
May, Tobias [Auteur]
Barbry, Pascal [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Bähr, Andrea [Auteur]
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
Klymiuk, Nikolai [Auteur]
Sirard, Jean-Claude [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Caballero, Ignacio [Auteur correspondant]
Infectiologie et Santé Publique [UMR ISP]
Titre de la revue :
American Journal of Respiratory Cell and Molecular Biology
Pagination :
378-389
Éditeur :
American Thoracic Society
Date de publication :
2021-10
ISSN :
1044-1549
Mot(s)-clé(s) en anglais :
Pseudomonas aeruginosa
cystic fibrosis
TLR5
inflammation
flagellin
cystic fibrosis
TLR5
inflammation
flagellin
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Immunologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
Résumé en anglais : [en]
Excessive lung inflammation and airway epithelium damage are hallmarks of human inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity provides protection against pathogens while reducing ...
Lire la suite >Excessive lung inflammation and airway epithelium damage are hallmarks of human inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity provides protection against pathogens while reducing lung-damaging inflammation. However, the mechanisms underlying innate immunity-mediated protection in the lung remain mysterious, in part because of the lack of appropriate animal models for these human diseases. Toll-like receptor 5 (TLR5) stimulation by its specific ligand, the bacterial protein flagellin, has been proposed to enhance protection against several respiratory infectious diseases, although other cellular events, such as calcium signaling, may also control the intensity of innate immune response. Here, we investigated the molecular events prompted by stimulation with flagellin and its role in regulating innate immunity in the lung of the pig, which is anatomically and genetically more similar to humans than rodent models. We found that flagellin treatment modulated NF-κB signaling and intracellular calcium homeostasis in airway epithelial cells. Flagellin pre-treatment reduced the NF-κB nuclear translocation and the expression of pro-inflammatory cytokines to a second flagellin stimulus as well as to Pseudomonas aeruginosa infection. Moreover, in vivo administration of flagellin decreased the severity of P. aeruginosa-induced pneumonia. Then, we confirmed these beneficial effects of flagellin in a pathological model of CF by using ex vivo precision-cut lung slices from a CF pig model. These results provide evidence that flagellin treatment contribute to a better regulation of the inflammatory response in inflammatory lung diseases such as CF.Lire moins >
Lire la suite >Excessive lung inflammation and airway epithelium damage are hallmarks of human inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity provides protection against pathogens while reducing lung-damaging inflammation. However, the mechanisms underlying innate immunity-mediated protection in the lung remain mysterious, in part because of the lack of appropriate animal models for these human diseases. Toll-like receptor 5 (TLR5) stimulation by its specific ligand, the bacterial protein flagellin, has been proposed to enhance protection against several respiratory infectious diseases, although other cellular events, such as calcium signaling, may also control the intensity of innate immune response. Here, we investigated the molecular events prompted by stimulation with flagellin and its role in regulating innate immunity in the lung of the pig, which is anatomically and genetically more similar to humans than rodent models. We found that flagellin treatment modulated NF-κB signaling and intracellular calcium homeostasis in airway epithelial cells. Flagellin pre-treatment reduced the NF-κB nuclear translocation and the expression of pro-inflammatory cytokines to a second flagellin stimulus as well as to Pseudomonas aeruginosa infection. Moreover, in vivo administration of flagellin decreased the severity of P. aeruginosa-induced pneumonia. Then, we confirmed these beneficial effects of flagellin in a pathological model of CF by using ex vivo precision-cut lung slices from a CF pig model. These results provide evidence that flagellin treatment contribute to a better regulation of the inflammatory response in inflammatory lung diseases such as CF.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
Fichiers
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525202/pdf
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- 2021_Lopez-Galvez_Am-J-Respi-Cell-Mol-Biol_vol-65_p-378-89.pdf
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