NASH-related increases in plasma bile acid ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
NASH-related increases in plasma bile acid levels depend on insulin resistance
Auteur(s) :
Grzych, Guillaume [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Chávez-Talavera, Oscar [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Descat, Amandine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Thuillier, Dorothée [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Verrijken, An [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Kouach, Mostafa [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Legry, Vanessa [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Verkindt, Hélène [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Raverdy, Violeta [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Legendre, Benjamin [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
van Gaal, Luc [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Goossens, Jean-Francois [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Lestrelin, Réjane [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Francque, Sven [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Pattou, François [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Haas, Joel [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Tailleux, Anne [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Staels, Bart [Auteur correspondant]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Chávez-Talavera, Oscar [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Descat, Amandine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Thuillier, Dorothée [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Verrijken, An [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Kouach, Mostafa [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Legry, Vanessa [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Verkindt, Hélène [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Raverdy, Violeta [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Legendre, Benjamin [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
van Gaal, Luc [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Goossens, Jean-Francois [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Lestrelin, Réjane [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Francque, Sven [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Pattou, François [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Haas, Joel [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Tailleux, Anne [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Staels, Bart [Auteur correspondant]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Titre de la revue :
JHEP Reports Innovation in Hepatology
Pagination :
100222
Éditeur :
Elsevier
Date de publication :
2021-04
ISSN :
2589-5559
Mot(s)-clé(s) en anglais :
ABOS
Biological Atlas of Severe Obesity
ADA
American Diabetes Association
BA
bile acids
Bile acids
C4
7alpha-hydroxy-4-cholesten-3-one
CA
cholic acid
CDCA
chenodeoxycholic acid
DCA
deoxycholic acid
Diabetes
FPG
fasting plasma glycaemia
FXR
farnesoid-X-receptor
GCA
glycocholic acid
GCDCA
glycochenodeoxycholic acid
GDCA
glycodeoxycholic acid
GHCA
glycohyocholic acid
GHDCA
glycohyodeoxycholic acid
GLCA
glycolithocholic acid
GUDCA
glycoursodeoxycholic acid
HCA
hyocholic acid
HDCA
hyodeoxycholic acid
HOMA2
homeostatic model assessment 2
HbA1c
glycated haemoglobin
IR
insulin resistance
Insulin resistance
LCA
lithocholic acid
MAFLD
metabolic associated fatty liver disease
NAFL
non-alcoholic fatty liver
NAFLD
non-alcoholic fatty liver disease
NASH
non-alcoholic steatohepatitis
OGTT
oral glucose tolerance test
Obesity
T2D
type 2 diabetes
TCA
taurocholic acid
TCDCA
taurochenodeoxycholic acid
TDCA
taurodeoxycholic acid
THCA
taurohyocholic acid
THDCA
taurohyodeoxycholic acid
TLCA
taurolithocholic acid
TUDCA
tauroursodeoxycholic acid
Translational study
UDCA
ursodeoxycholic acid.
Biological Atlas of Severe Obesity
ADA
American Diabetes Association
BA
bile acids
Bile acids
C4
7alpha-hydroxy-4-cholesten-3-one
CA
cholic acid
CDCA
chenodeoxycholic acid
DCA
deoxycholic acid
Diabetes
FPG
fasting plasma glycaemia
FXR
farnesoid-X-receptor
GCA
glycocholic acid
GCDCA
glycochenodeoxycholic acid
GDCA
glycodeoxycholic acid
GHCA
glycohyocholic acid
GHDCA
glycohyodeoxycholic acid
GLCA
glycolithocholic acid
GUDCA
glycoursodeoxycholic acid
HCA
hyocholic acid
HDCA
hyodeoxycholic acid
HOMA2
homeostatic model assessment 2
HbA1c
glycated haemoglobin
IR
insulin resistance
Insulin resistance
LCA
lithocholic acid
MAFLD
metabolic associated fatty liver disease
NAFL
non-alcoholic fatty liver
NAFLD
non-alcoholic fatty liver disease
NASH
non-alcoholic steatohepatitis
OGTT
oral glucose tolerance test
Obesity
T2D
type 2 diabetes
TCA
taurocholic acid
TCDCA
taurochenodeoxycholic acid
TDCA
taurodeoxycholic acid
THCA
taurohyocholic acid
THDCA
taurohyodeoxycholic acid
TLCA
taurolithocholic acid
TUDCA
tauroursodeoxycholic acid
Translational study
UDCA
ursodeoxycholic acid.
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Introduction: Plasma bile acids (BA) have been extensively studied as pathophysiological actors in Non-Alcoholic Steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of ...
Lire la suite >Introduction: Plasma bile acids (BA) have been extensively studied as pathophysiological actors in Non-Alcoholic Steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabetes (T2D), obesity and insulin resistance (IR). Here, we sought to dissect the relationship between NASH, T2D and plasma BA levels in a large patient cohort. Materials and Methods: Four groups of patients from the ABOS cohort (Clin Trials NCT01129297) were included based on presence or absence of histologically evaluated NASH with or without coincident T2D. Patients were matched for BMI, HOMA2-assessed IR, HbA 1c , age and gender. To study the effect of IR and BMI on the association of plasma BA and NASH, patients from the Hepadip study were included. In both cohorts, fasting plasma BA concentrations were measured. Results: Plasma BA concentrations were higher in NASH compared to No-NASH patients both in T2D and NoT2D patients from the ABOS cohort. As we previously reported that plasma BA levels were unaltered in NASH patients of the Hepadip cohort, we assessed the impact of BMI and IR on the association of NASH and BA on the combined BA datasets. Our results revealed that NASH-associated increases in plasma total cholic acid (CA) concentrations depend on the degree of HOMA2-assessed systemic IR, but not on -cell function nor on BMI.Lire moins >
Lire la suite >Introduction: Plasma bile acids (BA) have been extensively studied as pathophysiological actors in Non-Alcoholic Steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabetes (T2D), obesity and insulin resistance (IR). Here, we sought to dissect the relationship between NASH, T2D and plasma BA levels in a large patient cohort. Materials and Methods: Four groups of patients from the ABOS cohort (Clin Trials NCT01129297) were included based on presence or absence of histologically evaluated NASH with or without coincident T2D. Patients were matched for BMI, HOMA2-assessed IR, HbA 1c , age and gender. To study the effect of IR and BMI on the association of plasma BA and NASH, patients from the Hepadip study were included. In both cohorts, fasting plasma BA concentrations were measured. Results: Plasma BA concentrations were higher in NASH compared to No-NASH patients both in T2D and NoT2D patients from the ABOS cohort. As we previously reported that plasma BA levels were unaltered in NASH patients of the Hepadip cohort, we assessed the impact of BMI and IR on the association of NASH and BA on the combined BA datasets. Our results revealed that NASH-associated increases in plasma total cholic acid (CA) concentrations depend on the degree of HOMA2-assessed systemic IR, but not on -cell function nor on BMI.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Projet ANR :
Source :
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