Clinical features and risk of relapses in ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Clinical features and risk of relapses in children and adults with mogad
Author(s) :
Cobo-Calvo, Alvaro [Auteur]
Ruiz, Anne [Auteur]
Rollot, Fabien [Auteur]
Arrambide, Georgina [Auteur]
Deschamps, Romain [Auteur]
Maillart, Elisabeth [Auteur]
Papeix, Caroline [Auteur]
Audoin, Bertrand [Auteur]
Lepine, Anne Fabienne [Auteur]
Maurey, Helene [Auteur]
ZEPHIR, Helene [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Biotti, Damien [Auteur]
Ciron, Jonathan [Auteur]
Durand-Dubief, Francoise [Auteur]
Collongues, Nicolas [Auteur]
Ayrignac, Xavier [Auteur]
Labauge, Pierre [Auteur]
Pierre, Meyer [Auteur]
Thouvenot, Eric [Auteur]
Bourre, Bertrand [Auteur]
Montcuquet, Alexis [Auteur]
Cohen, Mikael [Auteur]
Horellou, Philippe [Auteur]
Tintore, Mar [Auteur]
De Seze, Jerome [Auteur]
Vukusic, Sandra [Auteur]
Deiva, Kumaran [Auteur]
Marignier, Romain [Auteur]
Ruiz, Anne [Auteur]
Rollot, Fabien [Auteur]
Arrambide, Georgina [Auteur]
Deschamps, Romain [Auteur]
Maillart, Elisabeth [Auteur]
Papeix, Caroline [Auteur]
Audoin, Bertrand [Auteur]
Lepine, Anne Fabienne [Auteur]
Maurey, Helene [Auteur]
ZEPHIR, Helene [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Biotti, Damien [Auteur]
Ciron, Jonathan [Auteur]
Durand-Dubief, Francoise [Auteur]
Collongues, Nicolas [Auteur]
Ayrignac, Xavier [Auteur]
Labauge, Pierre [Auteur]
Pierre, Meyer [Auteur]
Thouvenot, Eric [Auteur]
Bourre, Bertrand [Auteur]
Montcuquet, Alexis [Auteur]
Cohen, Mikael [Auteur]
Horellou, Philippe [Auteur]
Tintore, Mar [Auteur]
De Seze, Jerome [Auteur]
Vukusic, Sandra [Auteur]
Deiva, Kumaran [Auteur]
Marignier, Romain [Auteur]
Journal title :
Annals of neurology
Abbreviated title :
Ann. Neurol.
Publication date :
2020-09-21
ISSN :
1531-8249
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The main objective was to compare clinical features, disease course, and myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) dynamics between children and adults with MOG-Ab-associated disease (MOGAD).
This retrospective ...
Show more >The main objective was to compare clinical features, disease course, and myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) dynamics between children and adults with MOG-Ab-associated disease (MOGAD). This retrospective multicentric, national study included 98 children and 268 adults with MOGAD between January 2014 and September 2019. Cox regression model for recurrent time-to-event data and Kaplan-Meier curves for time to antibody negativity were performed for the objectives. Isolated optic neuritis was the most frequent clinical presentation in both children (40.8%) and adults (55.9%, p = 0.013), and acute disseminated encephalomyelitis syndrome was more frequent in children (36.7% vs 5.6%, p < 0.001). Compared to adults, children displayed better recovery (Expanded Disability Status Scale ≥ 3.0 at last follow-up reached only by 10 of 97 [10.3%] vs 66/247 [26.7%], p < 0.001). In the multivariate analysis, adults were at higher risk of relapse than children (hazard ratio = 1.41, 95% confidence interval [CI] = 1.12-1.78, p = 0.003). At 2 years, 64.2% (95% CI = 40.9-86.5) of nonrelapsing children became MOG-Ab negative compared to 14.1% (95% CI = 4.7-38.3) of relapsing children (log-rank p < 0.001), with no differences observed in adults (log-rank p = 0.280). MOGAD patients differ in the clinical presentation at onset, showing an age-related shift in the clinical features across age groups. Compared to children, adults have a higher risk of relapse and worse functional recovery. Finally, children with monophasic disease become MOG-Ab negative earlier than relapsing children, but this is not true in adults. Considering these differences, management and treatment guidelines should be considered independently in children and adults. ANN NEUROL 2021;89:30-41.Show less >
Show more >The main objective was to compare clinical features, disease course, and myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) dynamics between children and adults with MOG-Ab-associated disease (MOGAD). This retrospective multicentric, national study included 98 children and 268 adults with MOGAD between January 2014 and September 2019. Cox regression model for recurrent time-to-event data and Kaplan-Meier curves for time to antibody negativity were performed for the objectives. Isolated optic neuritis was the most frequent clinical presentation in both children (40.8%) and adults (55.9%, p = 0.013), and acute disseminated encephalomyelitis syndrome was more frequent in children (36.7% vs 5.6%, p < 0.001). Compared to adults, children displayed better recovery (Expanded Disability Status Scale ≥ 3.0 at last follow-up reached only by 10 of 97 [10.3%] vs 66/247 [26.7%], p < 0.001). In the multivariate analysis, adults were at higher risk of relapse than children (hazard ratio = 1.41, 95% confidence interval [CI] = 1.12-1.78, p = 0.003). At 2 years, 64.2% (95% CI = 40.9-86.5) of nonrelapsing children became MOG-Ab negative compared to 14.1% (95% CI = 4.7-38.3) of relapsing children (log-rank p < 0.001), with no differences observed in adults (log-rank p = 0.280). MOGAD patients differ in the clinical presentation at onset, showing an age-related shift in the clinical features across age groups. Compared to children, adults have a higher risk of relapse and worse functional recovery. Finally, children with monophasic disease become MOG-Ab negative earlier than relapsing children, but this is not true in adults. Considering these differences, management and treatment guidelines should be considered independently in children and adults. ANN NEUROL 2021;89:30-41.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Neuroinflammation & Multiple Sclerosis (NEMESIS)
Submission date :
2021-06-23T11:42:13Z