Sleep and circadian rhythms as possible ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Sleep and circadian rhythms as possible trait markers of suicide attempt in bipolar disorders: an actigraphy study
Author(s) :
Benard, V. [Auteur]
Etain, B. [Auteur]
Vaiva, G. [Auteur]
Boudebesse, C. [Auteur]
Yeim, S. [Auteur]
Benizri, C. [Auteur]
Brochard, H. [Auteur]
Bellivier, F. [Auteur]
Geoffroy, P. A. [Auteur]
Etain, B. [Auteur]
Vaiva, G. [Auteur]
Boudebesse, C. [Auteur]
Yeim, S. [Auteur]
Benizri, C. [Auteur]
Brochard, H. [Auteur]
Bellivier, F. [Auteur]
Geoffroy, P. A. [Auteur]
Journal title :
Journal of affective disorders
Abbreviated title :
J Affect Disord
Volume number :
244
Pages :
1-8
Publication date :
2018-09-18
ISSN :
1573-2517
Keyword(s) :
Bipolar disorders
Suicide
Suicide attempt
Circadian rhythms
Sleep
Insomnia
Suicide
Suicide attempt
Circadian rhythms
Sleep
Insomnia
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The poor prognostic of Bipolar disorders (BD) is closely linked to deaths by suicide. Sleep and circadian abnormalities are observed during all phases of BD and are also associated with suicide attempt (SA). In this context, ...
Show more >The poor prognostic of Bipolar disorders (BD) is closely linked to deaths by suicide. Sleep and circadian abnormalities are observed during all phases of BD and are also associated with suicide attempt (SA). In this context, this study sought to identify specific sleep and circadian rhythms markers associated with suicidal attempt in euthymic patients with BD. The sample (N = 236) comprised 3 groups: 147 patients with BD including 57 with a history of SA and 90 without (NoSA), and 89 healthy controls (HC). All participants were recorded during 21 days with actigraphy. SA was associated with women gender (p = 0.03), familial history of SA (p = 0.03), mixed episodes (p = 0.001), and benzodiazepines (p = 0.019). SA, compared to noSA, had a morning phase preference (p = 0.04), and were more vigorous on the circadian type inventory (p = 0.04), and tended to suffer more from insomnia (45% versus 25% respectively, p = 0.10). SA was also associated with an earlier onset of daily activity assessed with actigraphy (M10 onset: p = 0.01). Backward stepwise linear regression indicated that a combination of four variables (Gender, vigour, insomnia, M10onset) significantly differentiated patients with SA from NoSA (p = 0.03). Cross-sectional design, and no examination of suicidal behaviors' subgroups such as first attempters or repeaters, or violent suicide attempt. Woman gender, vigorous circadian type, insomnia and an earlier daily activity appeared independently associated with SA in BD. If these biomarkers are confirmed in prospective studies, they should be screened and used to prevent suicide, with the development of personal and targeted chronobiological treatments.Show less >
Show more >The poor prognostic of Bipolar disorders (BD) is closely linked to deaths by suicide. Sleep and circadian abnormalities are observed during all phases of BD and are also associated with suicide attempt (SA). In this context, this study sought to identify specific sleep and circadian rhythms markers associated with suicidal attempt in euthymic patients with BD. The sample (N = 236) comprised 3 groups: 147 patients with BD including 57 with a history of SA and 90 without (NoSA), and 89 healthy controls (HC). All participants were recorded during 21 days with actigraphy. SA was associated with women gender (p = 0.03), familial history of SA (p = 0.03), mixed episodes (p = 0.001), and benzodiazepines (p = 0.019). SA, compared to noSA, had a morning phase preference (p = 0.04), and were more vigorous on the circadian type inventory (p = 0.04), and tended to suffer more from insomnia (45% versus 25% respectively, p = 0.10). SA was also associated with an earlier onset of daily activity assessed with actigraphy (M10 onset: p = 0.01). Backward stepwise linear regression indicated that a combination of four variables (Gender, vigour, insomnia, M10onset) significantly differentiated patients with SA from NoSA (p = 0.03). Cross-sectional design, and no examination of suicidal behaviors' subgroups such as first attempters or repeaters, or violent suicide attempt. Woman gender, vigorous circadian type, insomnia and an earlier daily activity appeared independently associated with SA in BD. If these biomarkers are confirmed in prospective studies, they should be screened and used to prevent suicide, with the development of personal and targeted chronobiological treatments.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Plasticity and Subjectivity (PSY)
Submission date :
2021-06-23T13:40:47Z