Diagnosis associated with tau higher than ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Diagnosis associated with tau higher than 1200?pg/ml: insights from the clinical and laboratory practice
Author(s) :
Lehmann, S. [Auteur]
Paquet, C. [Auteur]
Malaplate-Armand, C. [Auteur]
Magnin, E. [Auteur]
Schraen, S. [Auteur]
Quillard-Muraine, Muriel [Auteur]
Bousiges, O. [Auteur]
Delaby, C. [Auteur]
Dumurgier, J. [Auteur]
Hugon, J. [Auteur]
Sablonniere, B. [Auteur]
Blanc, F. [Auteur]
Wallon, D. [Auteur]
Gabelle, A. [Auteur]
Laplanche, J. L. [Auteur]
Bouaziz-Amar, E. [Auteur]
Peoc''''h, K. [Auteur]
Paquet, C. [Auteur]
Malaplate-Armand, C. [Auteur]
Magnin, E. [Auteur]
Schraen, S. [Auteur]
Quillard-Muraine, Muriel [Auteur]
Bousiges, O. [Auteur]
Delaby, C. [Auteur]
Dumurgier, J. [Auteur]
Hugon, J. [Auteur]
Sablonniere, B. [Auteur]
Blanc, F. [Auteur]
Wallon, D. [Auteur]
Gabelle, A. [Auteur]
Laplanche, J. L. [Auteur]
Bouaziz-Amar, E. [Auteur]
Peoc''''h, K. [Auteur]
Journal title :
Clinica chimica acta; international journal of clinical chemistry
Abbreviated title :
Clin. Chim. Acta
Publication date :
2019-04-30
ISSN :
1873-3492
Keyword(s) :
Dementia
Alzheimer''s disease
Creutzfeldt-Jakob disease
Cerebrospinal fluid
Tau protein
14-3-3 protein
Alzheimer''s disease
Creutzfeldt-Jakob disease
Cerebrospinal fluid
Tau protein
14-3-3 protein
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Cerebrospinal fluid (CSF) biomarkers are valuable tools for the diagnosis of neurological diseases. We aimed to investigate within a retrospective multicentric study the final diagnosis associated with very ...
Show more >BACKGROUND: Cerebrospinal fluid (CSF) biomarkers are valuable tools for the diagnosis of neurological diseases. We aimed to investigate within a retrospective multicentric study the final diagnosis associated with very high CSF Tau levels and to identify patterns of biomarkers that would differentiate them in clinical practice, to help clinical biologists into physicians' counseling. METHODS: Within the national multicentric network ePLM, we included 1743 patients from January 1, 2008, to December 31, 2013, with CSF biomarkers assayed by the same Innotest assays (protein Tau, phospho-Tau [pTau], and Aβ 1-42). We identified 205 patients with protein Tau concentration higher than 1200 pg/mL and final diagnosis. RESULTS: Among those patients, 105 (51.2%) were suffering from Alzheimer's disease, 37 (18%) from sporadic Creuztfeldt-Jakob disease, and 63 (30.7%) from other neurological diseases including paraneoplastic/ central nervous system tumor, frontotemporal dementia, other diagnoses, amyloid angiopathy, Lewy body dementia, and infections of the central nervous system. Phospho-Tau, Aβ1-42 and Aβ1-42/pTau values differed significantly between the three groups of patients (p < .001). An Aβ1-42/pTau ratio between 4.7 and 9.7 was suggestive of other neurological diseases (threshold in AD: 8.3). CSF 14-3-3 was useful to discriminate Alzheimer's disease from Creuztfeldt-Jakob disease in case of Aβ1-42 concentrations <550 pg/mL or pTau>60 pg/mL. CONCLUSIONS: This work emphasizes the interest of a well-thought-out interpretation of CSF biomarkers in neurological diseases, particularly in the case of high Tau protein concentrations in the CSF.Show less >
Show more >BACKGROUND: Cerebrospinal fluid (CSF) biomarkers are valuable tools for the diagnosis of neurological diseases. We aimed to investigate within a retrospective multicentric study the final diagnosis associated with very high CSF Tau levels and to identify patterns of biomarkers that would differentiate them in clinical practice, to help clinical biologists into physicians' counseling. METHODS: Within the national multicentric network ePLM, we included 1743 patients from January 1, 2008, to December 31, 2013, with CSF biomarkers assayed by the same Innotest assays (protein Tau, phospho-Tau [pTau], and Aβ 1-42). We identified 205 patients with protein Tau concentration higher than 1200 pg/mL and final diagnosis. RESULTS: Among those patients, 105 (51.2%) were suffering from Alzheimer's disease, 37 (18%) from sporadic Creuztfeldt-Jakob disease, and 63 (30.7%) from other neurological diseases including paraneoplastic/ central nervous system tumor, frontotemporal dementia, other diagnoses, amyloid angiopathy, Lewy body dementia, and infections of the central nervous system. Phospho-Tau, Aβ1-42 and Aβ1-42/pTau values differed significantly between the three groups of patients (p < .001). An Aβ1-42/pTau ratio between 4.7 and 9.7 was suggestive of other neurological diseases (threshold in AD: 8.3). CSF 14-3-3 was useful to discriminate Alzheimer's disease from Creuztfeldt-Jakob disease in case of Aβ1-42 concentrations <550 pg/mL or pTau>60 pg/mL. CONCLUSIONS: This work emphasizes the interest of a well-thought-out interpretation of CSF biomarkers in neurological diseases, particularly in the case of high Tau protein concentrations in the CSF.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Alzheimer et Tauopathies
Submission date :
2021-06-23T13:43:14Z