Title :

Covid-19 in liver transplant recipients: the french sot covid registry

Author(s) :

Dumortier, Jerome [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Duvoux, Christophe [Auteur]
Service d'hépato-gastro-entérologie [APHP Henri Mondor]
Roux, Olivier [Auteur]
Hôpital Beaujon [AP-HP]
Altieri, Mario [Auteur]
CHU Caen
Barraud, Helene [Auteur]
CHU Trousseau [Tours]
Besch, Camille [Auteur]
Hôpital de Hautepierre [Strasbourg]
Caillard, Sophie [Auteur]
Hôpital de Hautepierre [Strasbourg]
Coilly, Audrey [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Conti, Filomena [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Dharancy, Sebastien [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Durand, Francois [Auteur]
Hôpital Beaujon [AP-HP]
Francoz, Claire [Auteur]
Hôpital Beaujon [AP-HP]
Garaix, Florentine [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Houssel-Debry, Pauline [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Kounis, Ilias [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Laverdure, Noemie [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Leroy, Vincent [Auteur]
Hôpital Henri Mondor
Mallet, Maxime [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Mazzola, Alessandra [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Meunier, Lucy [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Radenne, Sylvie [Auteur]
Service d'Hépatologie [Hôpital de la Croix-Rousse - HCL]
Richardet, Jean-Philippe [Auteur]
Hôpital Henri Mondor
Vanlemmens, Claire [Auteur]
Hôpital JeanMinjoz
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Saliba, Faouzi [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]

Journal title :

Clinics and Research in Hepatology and Gastroenterology

Abbreviated title :

Clin Res Hepatol Gastroenterol

Volume number :

45

Pages :

101639

Publication date :

2021-01-28

ISSN :

2210-741X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in organ transplant recipients remains limited. The aim of this registry-based ...
Show more >BACKGROUND: Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in organ transplant recipients remains limited. The aim of this registry-based observational study was to report the characteristics and clinical outcomes of liver transplant (LT) recipients included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. METHODS: COVID-19 was diagnosed in patients who had a positive PCR assay for SARS-CoV-2 or in presence of typical lung lesions on imaging or specific SARS-CoV-2 antibodies. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. RESULTS: Of the 104 patients, 67 were admitted to hospital and 37 were managed at home (including all 13 children). Hospitalized patients had a median age of 65.2 years (IQR: 58.1 - 73.2 years) and two thirds were men. Most common comorbidities included overweight (67.3%), hypertension (61.2%), diabetes (50.7%), cardiovascular disease (20.9%) and respiratory disease (16.4%). SARS-CoV-2 infection was identified after a median of 92.8 months (IQR: 40.1 - 194.7 months) from LT. During hospitalization, antimetabolites, mTOR inhibitor, and CNIs were withdrawn in 41.9%, 30.0% and 12.5% of patients, respectively. The composite endpoint of severe Covid-19 within 30 days after diagnosis was reached by 33.0% of the adult patients. The 30-day mortality rate was 20.0%, and 28.1% for hospitalized patients. Multivariate analysis identified that age was independently associated with mortality. CONCLUSIONS: In our large nationwide study, Covid-19 in LT recipients was associated with a high mortality rate.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:44:39Z
2024-01-29T12:13:36Z