Socioeconomic deprivation does not impact ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Socioeconomic deprivation does not impact liver transplantation outcome for hcc: a survival analysis from a national database
Author(s) :
Menahem, Benjamin [Auteur]
Service de Chirurgie Viscérale et Digestive [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Dejardin, Olivier [Auteur]
Pôle Recherche, Prévention et Santé Publique [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Alves, Arnaud [Auteur]
Service de Chirurgie Viscérale et Digestive [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Launay, Ludivine [Auteur]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Lubrano, Jean [Auteur]
Service de Chirurgie Viscérale et Digestive [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Duvoux, Christophe [Auteur]
Hôpital Henri Mondor
Laurent, Alexis [Auteur]
Hôpital Henri Mondor
Launoy, Guy [Auteur]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Service de Chirurgie Viscérale et Digestive [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Dejardin, Olivier [Auteur]
Pôle Recherche, Prévention et Santé Publique [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Alves, Arnaud [Auteur]
Service de Chirurgie Viscérale et Digestive [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Launay, Ludivine [Auteur]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Lubrano, Jean [Auteur]
Service de Chirurgie Viscérale et Digestive [CHU Caen]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Duvoux, Christophe [Auteur]
Hôpital Henri Mondor
Laurent, Alexis [Auteur]
Hôpital Henri Mondor
Launoy, Guy [Auteur]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Journal title :
Liver Transplantation
Abbreviated title :
Transplantation
Volume number :
105
Pages :
1061-1068
Publication date :
2021-05-01
ISSN :
1534-6080
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: To investigate the value of European deprivation index (EDI) and hepatocellular carcinoma (HCC) characteristics and their relationships with outcome after liver transplantation (LT).
METHODS: Patients undergoing ...
Show more >BACKGROUND: To investigate the value of European deprivation index (EDI) and hepatocellular carcinoma (HCC) characteristics and their relationships with outcome after liver transplantation (LT). METHODS: Patients undergoing LT for HCC were included from a national database (from "Agence de la Biomédecine" between 2006 and 2016. Characteristics of the patients were blindly extracted from the database. Thus, EDI was calculated in 5 quintiles and prognosis factors of survival were determined according to a Cox model. RESULTS: Among the 3865 included patients, 33.9% were in the fifth quintile (quintile 1, N = 562 [14.5%]; quintile 2, N = 647 [16.7%]; quintile 3, N = 654 [16.9%]; quintile 4, N = 688 [17.8%]). Patients in each quintile were comparable regarding HCC history, especially median size of HCC, number of nodules of HCC and alpha-fetoprotein score. In the univariate analysis of the crude survival, having >2 nodules of HCC before LT and time on waiting list were associated with a higher risk of death (P < 0.0001 and P = 0.03, respectively). EDI, size of HCC, model for end-stage liver disease score, Child-Pugh score were not statistically significant in the crude and net survival. In both survival, time on waiting list and number of HCC ≥2 were independent factor of mortality after LT for HCC (P = 0.009 and 0.001, respectively, and P = 0.03 and 0.02, respectively). CONCLUSIONS: EDI does not impact overall survival after LT for HCC. Number of HCC and time on waiting list are independent prognostic factors of survival after LT for HCC.Show less >
Show more >BACKGROUND: To investigate the value of European deprivation index (EDI) and hepatocellular carcinoma (HCC) characteristics and their relationships with outcome after liver transplantation (LT). METHODS: Patients undergoing LT for HCC were included from a national database (from "Agence de la Biomédecine" between 2006 and 2016. Characteristics of the patients were blindly extracted from the database. Thus, EDI was calculated in 5 quintiles and prognosis factors of survival were determined according to a Cox model. RESULTS: Among the 3865 included patients, 33.9% were in the fifth quintile (quintile 1, N = 562 [14.5%]; quintile 2, N = 647 [16.7%]; quintile 3, N = 654 [16.9%]; quintile 4, N = 688 [17.8%]). Patients in each quintile were comparable regarding HCC history, especially median size of HCC, number of nodules of HCC and alpha-fetoprotein score. In the univariate analysis of the crude survival, having >2 nodules of HCC before LT and time on waiting list were associated with a higher risk of death (P < 0.0001 and P = 0.03, respectively). EDI, size of HCC, model for end-stage liver disease score, Child-Pugh score were not statistically significant in the crude and net survival. In both survival, time on waiting list and number of HCC ≥2 were independent factor of mortality after LT for HCC (P = 0.009 and 0.001, respectively, and P = 0.03 and 0.02, respectively). CONCLUSIONS: EDI does not impact overall survival after LT for HCC. Number of HCC and time on waiting list are independent prognostic factors of survival after LT for HCC.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Submission date :
2021-07-06T12:45:06Z
2024-02-05T15:39:48Z
2024-02-05T15:39:48Z