Cannabis use is associated with a lower ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Cannabis use is associated with a lower risk of diabetes in chronic hepatitis c-infected patients (anrs co22 hepather cohort)
Author(s) :
Barre, Tangui [Auteur]
Nishimwe, Marie Liberee [Auteur]
Protopopescu, Camelia [Auteur]
Marcellin, Fabienne [Auteur]
Carrat, Fabrice [Auteur]
Dorival, Celine [Auteur]
Delarocque-Astagneau, Elisabeth [Auteur]
Larrey, Dominique [Auteur]
Bourliere, Marc [Auteur]
Petrov-Sanchez, Ventzislava [Auteur]
Simony, Melanie [Auteur]
Pol, Stanislas [Auteur]
Fontaine, Helene [Auteur]
Carrieri, Patrizia [Auteur]
Nishimwe, Marie Liberee [Auteur]
Protopopescu, Camelia [Auteur]
Marcellin, Fabienne [Auteur]
Carrat, Fabrice [Auteur]
Dorival, Celine [Auteur]
Delarocque-Astagneau, Elisabeth [Auteur]
Larrey, Dominique [Auteur]
Bourliere, Marc [Auteur]
Petrov-Sanchez, Ventzislava [Auteur]
Simony, Melanie [Auteur]
Pol, Stanislas [Auteur]
Fontaine, Helene [Auteur]
Carrieri, Patrizia [Auteur]
Journal title :
Journal of viral hepatitis
Abbreviated title :
J. Viral Hepat.
Publication date :
2020-08-18
ISSN :
1365-2893
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Chronic hepatitis C virus (HCV) infection is a risk factor of insulin resistance, and HCV-infected patients are at a high risk of developing diabetes. In the general population, research has shown the potential benefit of ...
Show more >Chronic hepatitis C virus (HCV) infection is a risk factor of insulin resistance, and HCV-infected patients are at a high risk of developing diabetes. In the general population, research has shown the potential benefit of cannabis use for the prevention of diabetes and related metabolic disorders. We aimed to test whether cannabis use is associated with a lower risk of diabetes in chronic HCV-infected patients. Chronic HCV-infected patients (n = 10 445) were selected from the French national, multicenter, observational ANRS CO22 Hepather cohort. Cross-sectional data collected at cohort enrollment were used to assess the association between patients' clinical and behavioural characteristics and the risk of diabetes. Logistic regression model was performed with cannabis use as the main independent variable and a significance level set at 5%. A similar model stratified by the presence of advanced liver fibrosis (FIB-4 > 3.25) was also run. After multivariable adjustment, current (AOR [95%CI]: 0.49 [0.38-0.63]) and former (0.81 [0.67-0.98], P < .001) cannabis use were both associated with a reduced odds of diabetes. Conversely, male gender, tobacco use, elevated BMI, poverty, being a migrant and advanced fibrosis were associated with increased odds of diabetes. The association between cannabis use and diabetes was maintained in the stratified analysis. In this large cross-sectional study of chronic HCV-infected patients, cannabis use was associated with a lower risk of diabetes independently of clinical and socio-behavioural factors. Further studies are needed to elucidate a potential causal link and shed light on cannabis compounds and mechanisms involved in this relationship.Show less >
Show more >Chronic hepatitis C virus (HCV) infection is a risk factor of insulin resistance, and HCV-infected patients are at a high risk of developing diabetes. In the general population, research has shown the potential benefit of cannabis use for the prevention of diabetes and related metabolic disorders. We aimed to test whether cannabis use is associated with a lower risk of diabetes in chronic HCV-infected patients. Chronic HCV-infected patients (n = 10 445) were selected from the French national, multicenter, observational ANRS CO22 Hepather cohort. Cross-sectional data collected at cohort enrollment were used to assess the association between patients' clinical and behavioural characteristics and the risk of diabetes. Logistic regression model was performed with cannabis use as the main independent variable and a significance level set at 5%. A similar model stratified by the presence of advanced liver fibrosis (FIB-4 > 3.25) was also run. After multivariable adjustment, current (AOR [95%CI]: 0.49 [0.38-0.63]) and former (0.81 [0.67-0.98], P < .001) cannabis use were both associated with a reduced odds of diabetes. Conversely, male gender, tobacco use, elevated BMI, poverty, being a migrant and advanced fibrosis were associated with increased odds of diabetes. The association between cannabis use and diabetes was maintained in the stratified analysis. In this large cross-sectional study of chronic HCV-infected patients, cannabis use was associated with a lower risk of diabetes independently of clinical and socio-behavioural factors. Further studies are needed to elucidate a potential causal link and shed light on cannabis compounds and mechanisms involved in this relationship.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Submission date :
2021-07-06T12:45:14Z