Title :

Segmental colectomy for ulcerative colitis: is there a place in selected patients without active colitis ? an international multicentric retrospective study in 72 patients

Author(s) :

Frontali, A. [Auteur]
Cohen, L. [Auteur]
Bridoux, Valérie [Auteur]
Myrelid, P. [Auteur]
Sica, G. [Auteur]
Poggioli, G. [Auteur]
Espin, E. [Auteur]
Beyer-Berjot, Laura [Auteur]
Laharie, David [Auteur]
Spinelli, Angela [Auteur]
Zerbib, P. [Auteur]
Sampietro, G. M. [Auteur]
Frasson, M. [Auteur]
Louis, E. [Auteur]
Danese, Silvio [Auteur]
Fumery, M. [Auteur]
Denost, Q. [Auteur]
Altwegg, R. [Auteur]
Nancey, Stéphane [Auteur]
Michelassi, F. [Auteur]
Treton, Xavier [Auteur]
Panis, Y. [Auteur]

Journal title :

Journal of Crohn's & colitis

Abbreviated title :

J Crohns Colitis

Publication date :

2020-06-04

ISSN :

1876-4479

Keyword(s) :

postoperative flare
ulcerative colitis
Segmental colectomy

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: The aim of this study was to report a multicentric experience of segmental colectomy (SC) in ulcerative colitis (UC) patients without active colitis in order to assess if SC can represent or not an alternative ...
Show more >OBJECTIVE: The aim of this study was to report a multicentric experience of segmental colectomy (SC) in ulcerative colitis (UC) patients without active colitis in order to assess if SC can represent or not an alternative to ileal pouch-anal anastomosis (IPAA). METHODS: All UC patients undergoing SC were included. Postoperative complications according to Clavien-Dindo's classification, long- term results and risk factors for postoperative colitis and reoperation for colitis on the remnant colon were assessed. RESULTS: 72 UC patients underwent: sigmoidectomy (n=28), right colectomy (n=24), proctectomy (n=11) or left colectomy (n=9) for colonic cancer (n=27), "diverticulitis" (n=17), colonic stenosis (n=5), dysplasia or polyps (n=8), and miscellaneous (n=15). Three patients died postoperatively and 5/69 patients (7%) developed early flare of UC within 3 months after SC. After a median follow-up of 40 months, 24/69 patients (35%) were reoperated after a median delay after SC of 19 months (range, 2-158): 22/24 (92%) underwent total colectomy and ileorectal anastomosis (n=9) or TCP (n=13) and 2/24 (8%) an additional SC. Reasons for reoperation were: colitis (n=14; 20%), cancer (n=3) or dysplasia (n=3), colonic stenosis (n=1), and unknown reason (n=3). Endoscopic score of colitis before SC was Mayo 2-3 in 5/5 (100%) patients with early flare vs 15/42 without (36%; p=0.0101) and in 9/12 (75%) patients with reoperation for colitis vs 11/35 without (31%; p=0.016). CONCLUSIONS: After segmental colectomy in UC patients, postoperative early colitis is rare (7%). Segmental colectomy could possibly represent an alternative to IPAA in selected UC patients without active colitis.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:49:14Z