Title :

Haplotype motif-based models for kir-genotype informed selection of hematopoietic cell donors fail to predict outcome of patients with myelodysplastic syndromes or secondary acute myeloid leukemia

Author(s) :

Schetelig, Johannes [Auteur]
Baldauf, Henning [Auteur]
Koster, Linda [Auteur]
Kuxhausen, Michelle [Auteur]
Heidenreich, Falk [Auteur]
De Wreede, Liesbeth C. [Auteur]
Spellman, Stephen [Auteur]
Van Gelder, Michel [Auteur]
Bruno, Benedetto [Auteur]
Onida, Francesco [Auteur]
Lange, Vinzenz [Auteur]
Massalski, Carolin [Auteur]
Potter, Victoria [Auteur]
Ljungman, Per [Auteur]
Schaap, Nicolaas [Auteur]
Hayden, Patrick J. [Auteur]
Lee, Stephanie J. [Auteur]
Krger, Nicolaus [Auteur]
Hsu, Kathy [Auteur]
Schmidt, Alexander H. [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Robin, Marie [Auteur]

Journal title :

Frontiers in Immunology

Abbreviated title :

Front Immunol

Volume number :

11

Pages :

584520

Publication date :

2020

ISSN :

1664-3224

Keyword(s) :

unrelated donor
donor selection
hematopoietic stem cell transplantation
KIR3DL1
KIR2DS1
KIR

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Results from registry studies suggest that harnessing Natural Killer (NK) cell reactivity mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of relapse after allogeneic Hematopoietic ...
Show more >Results from registry studies suggest that harnessing Natural Killer (NK) cell reactivity mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of relapse after allogeneic Hematopoietic Cell Transplantation (HCT). Several competing models have been developed to classify donors as KIR-advantageous or disadvantageous. Basically, these models differ by grouping donors based on distinct KIR-KIR-ligand combinations or by haplotype motif assignment. This study aimed to validate different models for unrelated donor selection for patients with Myelodysplatic Syndromes (MDS) or secondary Acute Myeloid Leukemia (sAML). In a joint retrospective study of the European Society for Blood and Marrow Transplantation (EBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR) registry data from 1704 patients with secondary AML or MDS were analysed. The cohort consisted mainly of older patients (median age 61 years) with high risk disease who had received chemotherapy-based reduced intensity conditioning and anti-thymocyte globulin prior to allogeneic HCT from well-matched unrelated stem cell donors. The impact of the predictors on Overall Survival (OS) and relapse incidence was tested in Cox regression models adjusted for patient age, a modified disease risk index, performance status, donor age, HLA-match, sex-match, CMV-match, conditioning intensity, type of T-cell depletion and graft type. KIRShow less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:49:26Z
2024-01-22T12:47:07Z