Impact of Chronic Obstructive Pulmonary ...
Document type :
Article dans une revue scientifique
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Title :
Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections
Author(s) :
Rouze, Anahita [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Boddaert, Pauline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Martin-Loeches, Ignacio [Auteur]
St James's University Hospital
Institut d'Investigacions Biomèdiques August Pi i Sunyer [IDIBAPS]
Povoa, Pedro [Auteur]
Universidade Nova de Lisboa = NOVA University Lisbon [NOVA]
Rodriguez, Alejandro [Auteur]
Ramdane, Nassima [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Salluh, Jorge [Auteur]
D'Or Institute for Research and Education [Rio de Janeiro]
Houard, Marion [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nseir, Saad [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lille Inflammation Research International Center (LIRIC) - U995
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Boddaert, Pauline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Martin-Loeches, Ignacio [Auteur]
St James's University Hospital
Institut d'Investigacions Biomèdiques August Pi i Sunyer [IDIBAPS]
Povoa, Pedro [Auteur]
Universidade Nova de Lisboa = NOVA University Lisbon [NOVA]
Rodriguez, Alejandro [Auteur]
Ramdane, Nassima [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Salluh, Jorge [Auteur]
D'Or Institute for Research and Education [Rio de Janeiro]
Houard, Marion [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nseir, Saad [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lille Inflammation Research International Center (LIRIC) - U995
Journal title :
Microorganisms
Abbreviated title :
Microorganisms
Volume number :
8
Pages :
165
Publisher :
MDPI AG
Publication date :
2020-01-23
ISSN :
2076-2607
English keyword(s) :
chronic obstructive pulmonary disease
ventilator-associated
lower respiratory tract infections
pneumonia
tracheobronchitis
mechanical ventilation
intensive care
ventilator-associated
lower respiratory tract infections
pneumonia
tracheobronchitis
mechanical ventilation
intensive care
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objectives: To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI). Methods: Planned ancillary ...
Show more >Objectives: To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI). Methods: Planned ancillary analysis of TAVeM study, including 2960 consecutive adult patients who received invasive mechanical ventilation (MV) > 48 h. COPD patients (n = 494) were compared to non-COPD patients (n = 2466). The diagnosis of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) was based on clinical, radiological and quantitative microbiological criteria. Results: No significant difference was found in VAP (12% versus 13%, p = 0.931), or VAT incidence (13% versus 10%, p = 0.093) between COPD and non-COPD patients. Among patients with VA-LRTI, Escherichia coli and Stenotrophomonas maltophilia were significantly more frequent in COPD patients as compared with non-COPD patients. However, COPD had no significant impact on multidrug-resistant bacteria incidence. Appropriate antibiotic treatment was not significantly associated with progression from VAT to VAP among COPD patients who developed VAT, unlike non-COPD patients. Among COPD patients, patients who developed VAT or VAP had significantly longer MV duration (17 days (9–30) or 15 (8–27) versus 7 (4–12), p < 0.001) and intensive care unit (ICU) length of stay (24 (17–39) or 21 (14–40) versus 12 (8–19), p < 0.001) than patients without VA-LRTI. ICU mortality was also higher in COPD patients who developed VAP (44%), but not VAT(38%), as compared to no VA-LRTI (26%, p = 0.006). These worse outcomes associated with VA-LRTI were similar among non-COPD patients. Conclusions: COPD had no significant impact on incidence or outcomes of patients who developed VAP or VAT.Show less >
Show more >Objectives: To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI). Methods: Planned ancillary analysis of TAVeM study, including 2960 consecutive adult patients who received invasive mechanical ventilation (MV) > 48 h. COPD patients (n = 494) were compared to non-COPD patients (n = 2466). The diagnosis of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) was based on clinical, radiological and quantitative microbiological criteria. Results: No significant difference was found in VAP (12% versus 13%, p = 0.931), or VAT incidence (13% versus 10%, p = 0.093) between COPD and non-COPD patients. Among patients with VA-LRTI, Escherichia coli and Stenotrophomonas maltophilia were significantly more frequent in COPD patients as compared with non-COPD patients. However, COPD had no significant impact on multidrug-resistant bacteria incidence. Appropriate antibiotic treatment was not significantly associated with progression from VAT to VAP among COPD patients who developed VAT, unlike non-COPD patients. Among COPD patients, patients who developed VAT or VAP had significantly longer MV duration (17 days (9–30) or 15 (8–27) versus 7 (4–12), p < 0.001) and intensive care unit (ICU) length of stay (24 (17–39) or 21 (14–40) versus 12 (8–19), p < 0.001) than patients without VA-LRTI. ICU mortality was also higher in COPD patients who developed VAP (44%), but not VAT(38%), as compared to no VA-LRTI (26%, p = 0.006). These worse outcomes associated with VA-LRTI were similar among non-COPD patients. Conclusions: COPD had no significant impact on incidence or outcomes of patients who developed VAP or VAT.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Collections :
Research team(s) :
Glycobiology in fungal Pathogenesis and Clinical Applications
Submission date :
2021-07-15T09:13:24Z
2021-08-25T07:32:03Z
2021-08-25T07:32:03Z
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