Vancomycin Functionalized Nanoparticles ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Vancomycin Functionalized Nanoparticles for Bactericidal Biomaterial Surfaces
Auteur(s) :
Pichavant, Loic [Auteur]
Carrie, Helene [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Minh Ngoc, Nguyen [Auteur]
Plawinski, Laurent [Auteur]
Durrieu, Marie-Christine [Auteur]
Heroguez, Valerie [Auteur]
Carrie, Helene [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Minh Ngoc, Nguyen [Auteur]
Plawinski, Laurent [Auteur]
Durrieu, Marie-Christine [Auteur]
Heroguez, Valerie [Auteur]
Titre de la revue :
Biomacromolecules
Nom court de la revue :
Biomacromolecules
Numéro :
17
Pagination :
1339-1346
Date de publication :
2016
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé :
In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy ...
Lire la suite >In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of α-norbornenyl-ω-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.Lire moins >
Lire la suite >In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of α-norbornenyl-ω-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Équipe(s) de recherche :
Modélisation biopharmaceutique et pharmacocinétique
Date de dépôt :
2019-02-26T17:11:47Z