Interaction between sphingosine ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study.
Auteur(s) :
Sferra, Roberta [Auteur]
Pompili, Simona [Auteur]
Ventura, Luca [Auteur]
Dubuquoy, Caroline [Auteur]
Speca, Silvia [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gaudio, Eugenio [Auteur]
Latella, Giovanni [Auteur]
Vetuschi, Antonella [Auteur]
Pompili, Simona [Auteur]
Ventura, Luca [Auteur]
Dubuquoy, Caroline [Auteur]
Speca, Silvia [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gaudio, Eugenio [Auteur]
Latella, Giovanni [Auteur]
Vetuschi, Antonella [Auteur]
Titre de la revue :
European Journal of Histochemistry
Nom court de la revue :
Eur J Histochem
Numéro :
62
Date de publication :
2018-07-24
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
A concomitant action of multiple profibrotic mediators appears crucial in the development and progression of fibrosis. Sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-beta/Smads pathways are ...
Lire la suite >A concomitant action of multiple profibrotic mediators appears crucial in the development and progression of fibrosis. Sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-beta/Smads pathways are both involved in pathogenesis of fibrosis in several organs by controlling differentiation of fibroblasts to myofibroblasts and the epithelial to-mesenchymal transition. However, their direct involvement in chronic colitis-associated fibrosis it is not yet known. In this study we evaluated the immunohistochemical expression of some proteins implicated in sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-beta/Smads pathways in Dextrane Sodium Sulphate (DSS)-induced colorectal fibrosis in mice. Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR. This study highlights the relationship between the two pathways and the possible role of SPHK1 in the intestinal fibrosis. These results, if confirmed by in vitro studies, may have important clinical implications in the development of new therapeutical approaches in inflammatory bowel disease.Lire moins >
Lire la suite >A concomitant action of multiple profibrotic mediators appears crucial in the development and progression of fibrosis. Sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-beta/Smads pathways are both involved in pathogenesis of fibrosis in several organs by controlling differentiation of fibroblasts to myofibroblasts and the epithelial to-mesenchymal transition. However, their direct involvement in chronic colitis-associated fibrosis it is not yet known. In this study we evaluated the immunohistochemical expression of some proteins implicated in sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-beta/Smads pathways in Dextrane Sodium Sulphate (DSS)-induced colorectal fibrosis in mice. Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR. This study highlights the relationship between the two pathways and the possible role of SPHK1 in the intestinal fibrosis. These results, if confirmed by in vitro studies, may have important clinical implications in the development of new therapeutical approaches in inflammatory bowel disease.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Équipe(s) de recherche :
Inflammatory digestive disease : pathophysiology and therapeutic targets developement
Date de dépôt :
2019-03-01T14:08:02Z
2024-03-05T12:03:55Z
2024-03-05T12:03:55Z
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