Titre :

HLA mismatched donors in patients with myelodysplastic syndrome: an EBMT registry analysis.

Auteur(s) :

Robin, Marie [Auteur]
Porcher, Raphael [Auteur]
Ruggeri, Annalisa [Auteur]
Blaise, Didier [Auteur]
Wolschke, Christine [Auteur]
Koster, Linda [Auteur]
Angelucci, Emanuele [Auteur]
Stolzel, Friedrich [Auteur]
Potter, Victoria [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Koc, Yener [Auteur]
Ciceri, Fabio [Auteur]
Finke, Jurgen [Auteur]
Labussiere-Wallet, Helene [Auteur]
Cascon Maria Jesus, Pascual [Auteur]
Verbeek, Mareike [Auteur]
Rambaldi, Alessandro [Auteur]
Cornelissen Jan, J [Auteur]
Chevallier, Patrice [Auteur]
Radia, Rohini [Auteur]
Nagler, Arnon [Auteur]
Fegueux, Nathalie [Auteur]
Gluckman, Eliane [Auteur]
De Witte, Theo [Auteur]
Kroger, Nicolaus [Auteur]

Titre de la revue :

Biology of blood and marrow transplantation

Nom court de la revue :

Biol. Blood Marrow Transplant.

Date de publication :

2018-08-30

ISSN :

1523-6536

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Recently, haploidentical transplantation (haplo) using post-transplant cyclophosphamide (PTCy) has been reported to give very encouraging results in patients with hematological malignancies. Patients who have no HLA-matched ...
Lire la suite >Recently, haploidentical transplantation (haplo) using post-transplant cyclophosphamide (PTCy) has been reported to give very encouraging results in patients with hematological malignancies. Patients who have no HLA-matched donor currently have the choice between a mismatched unrelated donor, an unrelated cord blood (CB) donor, and a haploidentical related donor. The aim of our study is to compare the outcome of patients with myelodysplastic syndrome (MDS) who have been transplanted from a haploidentical donor using PTCy, an HLA-mismatched unrelated donor (marrow or peripheral blood stem cells), or an unrelated mismatched CB donor. A total of 833 MDS patients from the European Group for Blood and Marrow Transplantation (EBMT) registry, transplanted between 2011 and 2016, were identified. The potential benefit of haplo was compared with mismatched unrelated and CB donors in an adjusted and weighted model taking into account potential confounders and other prognostic variables. Haplo was at lower risk of acute graft-versus-host disease (GVHD) than mismatched unrelated donor (P = .010) but at similar risk than CB. Progression-free survival was better after haplo (versus mismatched unrelated, P = .056; versus CB, P = .003) and overall survival tended to be superior after haplo (versus mismatched unrelated, P = .082; versus CB, P = .002). Nonrelapse mortality was not significantly different between haplo and mismatched unrelated donors. Relapse risk was not influenced by the type of donor. In conclusion, patients with MDS from the EBMT registry receiving hematopoietic stem cell transplantation from a haplo donor have significantly better outcome than those receiving hematopoietic stem cell transplantation from a CB donor and at least similar or better outcome than with a mismatched unrelated donor. Prospective studies comparing the type of donors will be needed to confirm this assumption.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Date de dépôt :

2019-03-01T14:17:39Z