Title :

Magnetic resonance imaging changes following natalizumab discontinuation in multiple sclerosis patients with progressive multifocal leukoencephalopathy.

Author(s) :

Hodel, Jerome [Auteur]
Bapst, Blanche [Auteur]
Outteryck, Olivier [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Verclytte, Sebastien [Auteur]
Deramecourt, Vincent [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Benadjaoud Mohamed, Amine [Auteur]
Pruvo, Jean Pierre [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Vermersch, Patrick [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Leclerc, Xavier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171

Journal title :

Multiple sclerosis (Houndmills, Basingstoke, England)

Abbreviated title :

Mult. Scler.

Pages :

1352458517750765

Publication date :

2018-01-01

ISSN :

1477-0970

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant. OBJECTIVE: Evaluating magnetic resonance imaging (MRI) changes following ...
Show more >BACKGROUND: Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant. OBJECTIVE: Evaluating magnetic resonance imaging (MRI) changes following natalizumab (NTZ) discontinuation and preceding PML-IRIS. METHODS: MRIs (including diffusion-weighted imaging (DWI), T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), post-contrast T1-weighted sequences) were performed every week following PML diagnosis in 11 consecutive NTZ-PML patients. PML expansion, punctate lesions, contrast-enhancement, and mass-effect/edema were evaluated on each MRI sequence, following NTZ discontinuation. RESULTS: PML-IRIS occurred from 26 to 89 days after NTZ discontinuation. MRI changes prior to early PML-IRIS appeared significantly more pronounced using DWI compared to T2-FLAIR imaging ( p < 0.003). Two DWI features (marked PML expansion, punctate lesions) systematically preceded contrast-enhancement. CONCLUSION: Subtle changes may occur on DWI preceding contrast-enhancement.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille
CNRS

Collections :

• Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
• Lille Inflammation Research International Center (LIRIC) - U995
• Troubles cognitifs dégénératifs et vasculaires - U1171

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:17:58Z