Magnetic resonance imaging changes following ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
29343163
Permalink :
Title :
Magnetic resonance imaging changes following natalizumab discontinuation in multiple sclerosis patients with progressive multifocal leukoencephalopathy.
Author(s) :
Hodel, Jerome [Auteur]
Bapst, Blanche [Auteur]
Outteryck, Olivier [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Verclytte, Sebastien [Auteur]
Deramecourt, Vincent [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Benadjaoud Mohamed, Amine [Auteur]
Pruvo, Jean Pierre [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Vermersch, Patrick [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Leclerc, Xavier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Bapst, Blanche [Auteur]
Outteryck, Olivier [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Verclytte, Sebastien [Auteur]
Deramecourt, Vincent [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Benadjaoud Mohamed, Amine [Auteur]
Pruvo, Jean Pierre [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Vermersch, Patrick [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Leclerc, Xavier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Journal title :
Multiple sclerosis (Houndmills, Basingstoke, England)
Abbreviated title :
Mult. Scler.
Pages :
1352458517750765
Publication date :
2018-01-01
ISSN :
1477-0970
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant. OBJECTIVE: Evaluating magnetic resonance imaging (MRI) changes following ...
Show more >BACKGROUND: Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant. OBJECTIVE: Evaluating magnetic resonance imaging (MRI) changes following natalizumab (NTZ) discontinuation and preceding PML-IRIS. METHODS: MRIs (including diffusion-weighted imaging (DWI), T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), post-contrast T1-weighted sequences) were performed every week following PML diagnosis in 11 consecutive NTZ-PML patients. PML expansion, punctate lesions, contrast-enhancement, and mass-effect/edema were evaluated on each MRI sequence, following NTZ discontinuation. RESULTS: PML-IRIS occurred from 26 to 89 days after NTZ discontinuation. MRI changes prior to early PML-IRIS appeared significantly more pronounced using DWI compared to T2-FLAIR imaging ( p < 0.003). Two DWI features (marked PML expansion, punctate lesions) systematically preceded contrast-enhancement. CONCLUSION: Subtle changes may occur on DWI preceding contrast-enhancement.Show less >
Show more >BACKGROUND: Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant. OBJECTIVE: Evaluating magnetic resonance imaging (MRI) changes following natalizumab (NTZ) discontinuation and preceding PML-IRIS. METHODS: MRIs (including diffusion-weighted imaging (DWI), T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), post-contrast T1-weighted sequences) were performed every week following PML diagnosis in 11 consecutive NTZ-PML patients. PML expansion, punctate lesions, contrast-enhancement, and mass-effect/edema were evaluated on each MRI sequence, following NTZ discontinuation. RESULTS: PML-IRIS occurred from 26 to 89 days after NTZ discontinuation. MRI changes prior to early PML-IRIS appeared significantly more pronounced using DWI compared to T2-FLAIR imaging ( p < 0.003). Two DWI features (marked PML expansion, punctate lesions) systematically preceded contrast-enhancement. CONCLUSION: Subtle changes may occur on DWI preceding contrast-enhancement.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
CNRS
Université de Lille
CHU Lille
CNRS
Collections :
Research team(s) :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Submission date :
2019-03-01T14:17:58Z