Clinical phenotypes and survival of ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Clinical phenotypes and survival of pre-capillary pulmonary hypertension in systemic sclerosis.
Author(s) :
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Montani, David [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Hassoun, Paul [Auteur]
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Le Pavec, Jerome [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Clerson, Pierre [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Sitbon, Olivier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Jais, Xavier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Savale, Laurent [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Weatherald, Jason [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Sobanski, Vincent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mathai Stephen, C [Auteur]
Shafiq, Majid [Auteur]
Cordier, Jean-Francois [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Simonneau, Gerald [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Humbert, Marc [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Lille Inflammation Research International Center - U 995 [LIRIC]
Montani, David [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Hassoun, Paul [Auteur]
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Le Pavec, Jerome [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Clerson, Pierre [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Sitbon, Olivier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Jais, Xavier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Savale, Laurent [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Weatherald, Jason [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Sobanski, Vincent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mathai Stephen, C [Auteur]
Shafiq, Majid [Auteur]
Cordier, Jean-Francois [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Simonneau, Gerald [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Humbert, Marc [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Journal title :
PLoS ONE
Abbreviated title :
PLoS One
Volume number :
13
Pages :
e0197112
Publication date :
2018-05-15
ISSN :
1932-6203
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) is a heterogeneous condition with an overall bad prognosis. The objective of this study was to identify and characterize homogeneous phenotypes by a ...
Show more >Pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) is a heterogeneous condition with an overall bad prognosis. The objective of this study was to identify and characterize homogeneous phenotypes by a cluster analysis in SSc patients with PH. Patients were identified from two prospective cohorts from the US and France. Clinical, pulmonary function, high-resolution chest tomography, hemodynamic and survival data were extracted. We performed cluster analysis using the k-means method and compared survival between clusters using Cox regression analysis. Cluster analysis of 200 patients identified four homogenous phenotypes. Cluster C1 included patients with mild to moderate risk pulmonary arterial hypertension (PAH) with limited or no interstitial lung disease (ILD) and low DLCO with a 3-year survival of 81.5% (95% CI: 71.4–88.2). C2 had pre-capillary PH due to extensive ILD and worse 3-year survival compared to C1 (adjusted hazard ratio [HR] 3.14; 95% CI 1.66–5.94; p = 0.0004). C3 had severe PAH and a trend towards worse survival (HR 2.53; 95% CI 0.99–6.49; p = 0.052). Cluster C4 and C1 were similar with no difference in survival (HR 0.65; 95% CI 0.19–2.27, p = 0.507) but with a higher DLCO in C4. PH in SSc can be characterized into distinct clusters that differ in prognosis.Show less >
Show more >Pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) is a heterogeneous condition with an overall bad prognosis. The objective of this study was to identify and characterize homogeneous phenotypes by a cluster analysis in SSc patients with PH. Patients were identified from two prospective cohorts from the US and France. Clinical, pulmonary function, high-resolution chest tomography, hemodynamic and survival data were extracted. We performed cluster analysis using the k-means method and compared survival between clusters using Cox regression analysis. Cluster analysis of 200 patients identified four homogenous phenotypes. Cluster C1 included patients with mild to moderate risk pulmonary arterial hypertension (PAH) with limited or no interstitial lung disease (ILD) and low DLCO with a 3-year survival of 81.5% (95% CI: 71.4–88.2). C2 had pre-capillary PH due to extensive ILD and worse 3-year survival compared to C1 (adjusted hazard ratio [HR] 3.14; 95% CI 1.66–5.94; p = 0.0004). C3 had severe PAH and a trend towards worse survival (HR 2.53; 95% CI 0.99–6.49; p = 0.052). Cluster C4 and C1 were similar with no difference in survival (HR 0.65; 95% CI 0.19–2.27, p = 0.507) but with a higher DLCO in C4. PH in SSc can be characterized into distinct clusters that differ in prognosis.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Research team(s) :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Submission date :
2019-03-01T14:26:53Z
2024-01-25T12:29:08Z
2024-01-25T12:29:08Z
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